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New Products in Online Store: “CDH Hero” Shirts for Men, Women, Kids, and Infants!

Click below to see our newest additions to the CDH Awareness Shop!  “My brother is my hero” WOMEN’S  |  MEN’S  |  KIDS  |  INFANTS “My sister is my hero” WOMEN’S  |  MEN’S  |  KIDS  |  INFANTS “My daughter is my hero” WOMEN’S  |  MEN’S “My son is my hero” WOMEN’S  |  MEN’S  “My grandson is my hero” WOMEN’S |  MEN’S …

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RESEARCH: “Lowest PaCO2 on the first day of life predicts mortality and morbidity among infants with congenital diaphragmatic hernia.”

Retrospective review of patients entered into the CDHSG registry between 2007-2014. Half of the identified patients were analyzed to identify the PaCO2 value most predictive of mortality. Prediction models for outcomes of death, ECMO, and respiratory support at 30 days of life (DOL) were developed using PaCO2. Remaining half of data was used for validation …

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RESEARCH: “Prenatal treatment with rosiglitazone attenuates vascular remodeling and pulmonary monocyte influx in experimental congenital diaphragmatic hernia.”

Extensive vascular remodeling causing pulmonary hypertension (PH) represents a major cause of mortality in patients with congenital diaphragmatic hernia (CDH). The chemokine monocyte chemoattractant protein-1 (MCP-1) is a biomarker for the severity of PH and its activation is accompanied by pulmonary influx of monocytes and extensive vascular remodeling. MCP-1 activation can be reversed by application …

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RESEARCH: “Health-related quality of life, educational and family outcomes in survivors of congenital diaphragmatic hernia.”

Congenital diaphragmatic hernia (CDH) survivors experience increased risk of medical and neurodevelopmental challenges. This study describes the health-related quality of life (HRQOL), special education utilization and the family impact among neonatal CDH survivors. Read more HERE.

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RESEARCH: “Relationship between volume and outcome for congenital diaphragmatic hernia: a systematic review protocol.”

Congenital diaphragmatic hernia is a rare and life-threatening anomaly that occurs during fetal development and results in an incomplete or incorrect formation of the diaphragm. Surgical therapy of the diaphragm should be performed after clinical stabilization of the neonate. Higher hospital or surgeon volume has previously been found to be associated with better clinical outcomes …

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RESEARCH: “Congenital diaphragmatic hernia in newborn infants: Variable endotracheal tube and umbilical venous catheter positions”

We reviewed the radiographs of 131 infants with congenital diaphragmatic hernia and report that the umbilical venous catheter usually deviates to the ipsilateral and the endotracheal tube to the contralateral side of the defect. The trachea and the umbilical vein, however, can be found on either side of the midline. Read more HERE.

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Current Fundraisers: Week of November 11th

Here is a list of the current Facebook fundraisers benefiting CDH International and CHERUBS: Angie’s Birthday Fundraiser Kim’s Birthday Fundraiser Tara’s Birthday Fundraiser Brittany’s Birthday Fundraiser Michelle’s Birthday Fundraiser Raising Money For a Cause I Care About by Jamillah Iesha Burns Kevin’s Birthday Fundraiser Patricia’s Birthday Fundraiser Kali’s Birthday Fundraiser Ellie’s birthday fundraiser RoEu’s Birthday Fundraiser Abdy’s …

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RESEARCH: “Sildenafil Use in Children with Pulmonary Hypertension.”

OBJECTIVE: To assess the demographics, treatment algorithm, and outcomes in a large cohort of children treated with sildenafil. STUDY DESIGN: A retrospective cohort study of children with pulmonary hypertension (PH) treated with sildenafil at a single institution between 2004 and 2015. Baseline and follow-up data collected by chart review. To read more, click HERE.

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RESEARCH: “Cervical Measurement and Pessary Application in Relation to Gestational Age at Delivery in Patients Treated with Fetoscopic Endotracheal Occlusion.”

OBJECTIVE: To evaluate the impact of cervical length and cervical pessary application in congenital diaphragmatic hernia (CDH) treated by the fetoscopic endotracheal occlusion (FETO) procedure. METHODS: The study group consisted of 80 patients with severe CDH treated by FETO. Cervical length measurement was performed by transvaginal ultrasound in all patients within the 24 h prior …

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RESEARCH: “Assessment of the nitrofen model of congenital diaphragmatic hernia and of the dysregulated factors involved in pulmonary hypoplasia.”

To study pulmonary hypoplasia (PH) associated with congenital diaphragmatic hernia (CDH), investigators have been employing a fetal rat model based on nitrofen administration to dams. Herein, we aimed to: (1) investigate the validity of the model, and (2) synthesize the main biological pathways implicated in the development of PH associated with CDH. To read more, …

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RESEARCH: “Endoplasmic reticulum stress response is activated in pulmonary hypoplasia secondary to congenital diaphragmatic hernia, but is decreased by administration of amniotic fluid stem cells.”

Pulmonary hypoplasia secondary to congenital diaphragmatic hernia (CDH) is characterized by impaired epithelial homeostasis. Recently, amniotic fluid stem cells (AFSCs) have been shown to promote growth in hypoplastic lungs of rat fetuses with CDH. Herein, we investigated whether CDH hypoplastic lungs mount an endoplasmic reticulum (ER) stress response and whether AFSCs could re-establish pulmonary epithelial …