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CDHi Attends the 51st Annual Meeting of Pacific Association of Pediatric Surgeons

Last week, CDHi attended the 51st annual meeting of Pacific Association of Pediatric Surgeons in Sapporo, Japan. It  was a wonderful opportunity to see some of our Medical Advisory Board members and meet new surgeons from Asia and Australia. We’re thrilled to have made new connections with people who are just as passionate about CDH …

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RESEARCH: Treprostinil Improves Persistent Pulmonary Hypertension Associated with Congenital Diaphragmatic Hernia

We conducted a retrospective cohort study of infants with CDH-associated pulmonary hypertension treated with treprostinil from January 2011 to September 2016. Severity of pulmonary hypertension was assessed by echocardiogram and serum B-type natriuretic peptide (BNP) by using time points before initiation and 24 hours, 1 week, and 1 month after treprostinil initiation. Fisher exact tests, …

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RESEARCH: Feasibility of non-invasive Neurally adjusted ventilator assist after congenital diaphragmatic hernia repair

The use of neurally adjusted ventilator assist (NAVA) in congenital diaphragmatic hernia (CDH) patients has been historically deemed unwise, since the trigger for breaths is the electromyographic activity of the diaphragmatic muscle. We report on our NAVA experience in CDH patients. Read more HERE.

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CDHi Welcomes New Medical Advisory Board Member, Mauro Longoni

CDH International is very happy to welcome our long-time friend, Dr. Mauro Longoni, officially to our Medical Advisory Board.   Dr. Longoni is part of the genetic research team at Boston Children’s Hospital and has spoken at CHERUBS conferences many times over the years.   He is an adamant supporter of the charity and families affected by …

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Research: “Systematic analysis of copy number variation associated with congenital diaphragmatic hernia”

Abstract: Congenital diaphragmatic hernia (CDH), characterized by malformation of the diaphragm and hypoplasia of the lungs, is one of the most common and severe birth defects, and is associated with high morbidity and mortality rates. There is growing evidence demonstrating that genetic factors contribute to CDH, although the pathogenesis remains largely elusive. Single-nucleotide polymorphisms have …

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CDH International Participates in the Pacific Association of Pediatric Surgeons

CDHi was representing by our President, Dawn Ireland, at the 2018 PAPS conference in Sapporo, Japan this week.   Pediatric surgeons came from all over the Pacific to share research and collaborate.   Also attending were two of our Medical Advisors, Jay Wilson and Kevin Lally. By attending this conference, we were able to hear more research …

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Research: “Congenital Diaphragmatic Hernia and Eventration”

Abstract Congenital diaphragmatic hernia (CDH) has an incidence of 1 in 2500 live births in the UK. CDH is a defect in the fetal diaphragm which allows the contents of the abdominal cavity to protrude into the thorax. CDH may be associated with other major anomalies. The defect may be diagnosed in the fetus, newborn …

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Research: “Congenital Diaphragmatic Hernia”

Abstract Over the past 20 years, prenatal detection of congenital diaphragmatic hernia (CDH) has improved worldwide, reaching up to 60% in Europe. Pulmonary hypoplasia and persistent pulmonary hypertension are the two main determinants of neonatal mortality and morbidity, so new tools have been focused on their evaluation. Fetal surgery for severe cases requires proper evaluation …

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Research: “Prenatal intervention for the management of congenital diaphragmatic hernia”

Abstract Congenital diaphragmatic hernia (CDH) is the result of incomplete formation of the diaphragm that occurs during embryogenesis. The defect in the diaphragm permits the herniation of abdominal organs into the thoracic cavity contributing to the impairment of normal growth and development of the fetal lung. In addition to the hypoplastic lung, anomalies of the …

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Research: “A Case of Incarcerated Traumatic Diaphragmatic Hernia”

Abstract A 74-year-old woman was admitted to our hospital because of back pain and difficulty of breathing, which started the previous night. She had a history of multiple traumas caused by a traffic accident 4 months prior. She was developing a shock but showed no signs of peritonitis. A computed tomography scan showed dilation of …

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Research: “Treatment of rat congenital diaphragmatic hernia with sildenafil and NS-304, selexipag’s active compound, at the pseudoglandular stage improves lung vasculature.”

Patients with congenital diaphragmatic hernia (CDH) often suffer from severe pulmonary hypertension and the choice of current vasodilator therapy is mostly based on trial and error. Since pulmonary vascular abnormalities are already present early during development, we performed a study to modulate these pulmonary vascular changes at an early stage during gestation. Read more HERE.

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