J Perinatol
. 2026 Feb 23.
doi: 10.1038/s41372-026-02582-4. Online ahead of print.
A hemodynamic-driven approach to chronic pulmonary hypertension in congenital diaphragmatic hernia
Carly E Byrd # 1, John T Wren Jr # 2, Suneetha Desiraju 1, Patrick J McNamara 3
Affiliations Expand
- PMID: 41731046
- DOI: 10.1038/s41372-026-02582-4
Abstract
Despite ample research in acute pulmonary hypertension in neonates with congenital diaphragmatic hernia (CDH) leading to improved survival, there is a paucity of literature on the physiology of chronic pulmonary hypertension in this population. Serial hemodynamic assessments and physiology-centric care have been shown to be safe and effective in the acute transitional and peri-operative care of these neonates and will likely be informative in the discussion of chronic pulmonary hypertension as well. Herein, we discuss the epidemiology, contributors, and proposed physiology-based phenotypes of chronic pulmonary hypertension in neonates with CDH. Further investigation is needed to contribute to our understanding and treatment of chronic pulmonary hypertension in this complex, heterogeneous population.
© 2026. The Author(s).
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