Extracell Vesicles Circ Nucl Acids
. 2025 Jul 10;6(3):350-354.
doi: 10.20517/evcna.2025.25. eCollection 2025. https://pubmed.ncbi.nlm.nih.gov/41132498/
A new hope for pulmonary hypoplasia: amniotic fluid stem cell extracellular vesicles?
Ishara Atukorala 1 2 3, Lisa Hui 1 2 3 4
Affiliations Expand
- PMID: 41132498
- PMCID: PMC12540043
- DOI: 10.20517/evcna.2025.25
Abstract
In a recent study, Antounians and colleagues (2024) investigated the potential of amniotic fluid stem cell-derived extracellular vesicles (AFSC-EVs) as a therapeutic intervention for pulmonary hypoplasia resulting from congenital diaphragmatic hernia (CDH). They demonstrated the pronounced inflammatory signature of the fetal hypoplastic lungs, marked by heightened macrophage density in a CDH rat model. Intra-amniotic AFSC-EV administration mitigated the inflammatory process and enhanced fetal lung development by promoting branching morphogenesis and epithelial maturation. These findings add to a growing body of preclinical and clinical evidence supporting the therapeutic potential of AFSC-EVs for inflammation-driven pathologies.
Keywords: Extracellular vesicles; amniotic fluid stem cells; inflammation; pulmonary hypoplasia.
© The Author(s) 2025.
