J Perinatol
. 2025 Aug 18.
doi: 10.1038/s41372-025-02389-9. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/40825864/
Antibiotic exposure and infection epidemiology among newborns with congenital diaphragmatic hernia
Sabrina J Flohr 1, Leny Mathew 1, Holly L Hedrick 1 2, Natalie E Rintoul 1 3, Talene A Metjian 4, Sanjeev K Swami 5, Jeffrey S Gerber 5, Alexandra K Medoro 3 5, Dustin D Flannery 6
Affiliations Expand
- PMID: 40825864
- DOI: 10.1038/s41372-025-02389-9
Abstract
Objective: To describe infection epidemiology and measure antibiotic utilization among a large cohort of newborns with congenital diaphragmatic hernia (CDH).
Study design: Retrospective observational study including inborn newborns with CDH at a level IV referral center (free-standing children’s hospital with special delivery unit) and two associated level III birth centers who underwent active care and survived to NICU admission, born 1/2013-11/2022 with available disposition.
Results: Of 381 newborns with CDH who were admitted to the NICU, 370 (97.1%) received antibiotics. There were 137 (36.1%) newborns with a positive bacterial culture from any source; 78/381 (20.4%) had a positive culture from blood, urine, or spinal fluid.
Conclusion: Nearly all newborns with CDH at our center received antibiotics during their hospitalization, but the majority did not have a positive bacterial culture result, indicating opportunities exist for antibiotic stewardship among this population.
© 2025. The Author(s), under exclusive licence to Springer Nature America, Inc.
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