J Perinatol
. 2026 Jun 22.
doi: 10.1038/s41372-026-02749-z. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/42332047/
Association between vasoactive-inotropic score, clinical outcomes, defect size and laterality in congenital diaphragmatic hernia
Andrew M Beverstock 1, Joseph L Hagan 2, Morcos Hanna 2, Caraciolo J Fernandes 2, Sharada H Gowda 2 3
Affiliations Expand
- PMID: 42332047
- DOI: 10.1038/s41372-026-02749-z
Abstract
Objective: To assess whether vasoactive-inotropic score (VIS) during early life was predictive of outcomes for infants with congenital diaphragmatic hernia and to determine whether VIS differed by defect size and laterality.
Study design: Retrospective single-center cohort study of 206 infants with CDH. VIS was calculated at 6, 12, 24, 48 and 72 h of life as well as at repair, 24 h and 48 h-post repair.
Result: Higher VIS scores at all time points were associated with an increased risk of mechanical ventilation at 28 days of life (p < 0.02). VIS in the first 24 h was associated with an increased risk ECMO or death (p < 0.001) and tracheostomy or death (p < 0.02). VIS did not differ between left and right defects, but larger defects had higher scores.
Conclusion: Early-life VIS scores at 6, 12 and 24 h have predictive value for extended duration of mechanical ventilation, ECMO, tracheostomy or death.
© 2026. The Author(s).
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