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Research: Discordant prenatal ultrasound and fetal MRI in CDH: wherein lies the truth?

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Research: Discordant prenatal ultrasound and fetal MRI in CDH: wherein lies the truth?

J Pediatr Surg. 2019 Nov 26. pii: S0022-3468(19)30840-1. doi: 10.1016/j.jpedsurg.2019.11.007. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/31813580

Discordant prenatal ultrasound and fetal MRI in CDH: wherein lies the truth?

Kim AG1Norwitz G2Karmakar M2Ladino-Torres M3Berman DR4Kreutzman J1Treadwell MC4Mychaliska GB1Perrone EE5.

Author information

Abstract

PURPOSE:

Prenatal risk assessment of congenital diaphragmatic hernia (CDH) relies on prenatal ultrasound (U/S) and fetal magnetic resonance imaging (MRI). When the modalities differ in prognosis, it is unclear which is more reliable.

METHODS:

Retrospective chart review identified cases of prenatally diagnosed CDH from 4/2010-6/2018 meeting inclusion criteria. Demographic, radiologic, and postnatal outcomes data were collected. Ultrasound- versus MRI-based prognosis (mild, moderate, and severe) was compared with clinical outcomes. Kappa measures compared congruency in disease severity scaling between imaging modalities, while logistic regression and receiver operating characteristics curves compared the ability of each modality to predict outcomes.

RESULTS:

Forty-two patients met criteria. Both U/S- and MRI-based prognosis categories differentiated for survival. MRI categories differentiated for ECMO use, surgical repair, and defect type. O/e TFLV better discriminated for survivors and defect type than o/e LHR. Seventeen (40.5%) had discordant prenatal prognostic categories. In 13/17 (76.5%), o/e TFLV predicted higher severity when compared to o/e LHR, but sample size was insufficient to compare accuracy in cases of discordance.

CONCLUSIONS:

Clinical outcomes suggest fetal MRI may more accurately predict severe pulmonary hypoplasia compared to prenatal ultrasound. Our analysis suggests fetal MRI is a valuable adjunct in the prenatal evaluation of CDH.

LEVEL OF EVIDENCE:

Level III.

TYPE OF STUDY:

Retrospective Review.

Copyright © 2019 Elsevier Inc. All rights reserved.

KEYWORDS:

Congenital diaphragmatic hernia; Fetal; Magnetic resonance imaging; Prognosis; UltrasoundPMID: 31813580 DOI: 10.1016/j.jpedsurg.2019.11.007

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