Prenat Diagn
. 2025 Apr 29.
doi: 10.1002/pd.6803. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/40302114/
Fetal Endoscopic Tracheal Occlusion (FETO) for Left and Right Congenital Diaphragmatic Hernia in Canada
Yada Kunpalin 1 2, Anna Otvodenko 1, Tim Van Mieghem 1 2, Priscilla P L Chiu 2 3, Paolo Campisi 2 4, Shiri Shinar 1 2, Prakesh S Shah 2 5, Christina Marrata 2 6, Dilkash Kajal 2 7, Greg Ryan 1 2, Nimrah Abbasi 1 2
Affiliations Expand
- PMID: 40302114
- DOI: 10.1002/pd.6803
Abstract
Objective: To describe perinatal and short-term pediatric outcomes and procedural safety of fetal endoscopic tracheal occlusion (FETO) in a Canadian national referral centre.
Methods: Retrospective study including all consecutive FETO cases at the Ontario Fetal Centre between 2010 and 2024. Maternal and fetal baseline characteristics, technical aspects and short-term outcomes until 6 months are described.
Results: FETO was successfully performed in 47/48 (98%) cases at an average gestational age (GA) of 28.5 (24-31.6) weeks including 22 (47%) moderate LCDH (M-LCDH), 12 (25%) severe LCDH (S-LCDH) and 13 (28%) right CDH (RCDH). There were no major complications. Balloon removals were emergent in 23/46 (50%) and challenging in 14/46 (30%) of cases. Preterm premature rupture of membranes (< 37 weeks) occurred in 70% (33/47) with average GA at birth of 35.9 weeks (29.0-40.4 weeks). Survival to discharge was 54% (25/46), specifically 64% (14/22), 33% (4/12), and 58% (7/12) among M-LCDH, S-LCDH and RCDH, respectively. Patch repair was performed in 28/30 (93%). Supplemental oxygen and tube feeding were required in 32% (8/25) and 68% (15/22) of survivors at discharge, respectively.
Conclusions: In this North American series, FETO outcomes were similar to those observed in international trials, confirming its effectiveness. Studies are ongoing to evaluate long-term outcomes.
Keywords: CDH; congenital diaphragmatic hernia; fetal surgery; fetal therapy; fetoscopy; prenatal; tracheal occlusion; ultrasound.
© 2025 The Author(s). Prenatal Diagnosis published by John Wiley & Sons Ltd.
