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Research: Image-based prenatal predictors correlate with postnatal survival, extracorporeal life support use, and defect size in left congenital diaphragmatic hernia

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Research: Image-based prenatal predictors correlate with postnatal survival, extracorporeal life support use, and defect size in left congenital diaphragmatic hernia

J Perinatol

. 2022 Feb 28. doi: 10.1038/s41372-022-01357-x. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35228684/

Image-based prenatal predictors correlate with postnatal survival, extracorporeal life support use, and defect size in left congenital diaphragmatic hernia

Erin E Perrone 1Monita Karmakar 2Pamela A Lally 3Sukyung Chung 4Florian Kipfmueller 5Francesco Morini 6Ryan Phillips 7Krisa P Van Meurs 8Matthew T Harting 3George B Mychaliska 2Kevin P Lally 3Congenital Diaphragmatic Hernia Study GroupAffiliations expand

Abstract

Objective: To evaluate the association between prenatal imaging predictors of patients with left-sided congenital diaphragmatic hernia (LCDH) and postnatal outcomes.

Study design: CDH study group data were reviewed for LCDH infants born 2015-2019. Prenatal ultrasound (US) and magnetic resonance imaging (MRI) data were collected and correlated with postnatal information including CDHSG defect size (A through D or non-repair (NR)).

Results: In total, 929 LCDH patients were included. Both US and MRI imaging predictors correlated with postnatal survival (72.2%) and ECLS use (29.6%). Logistic regression models confirmed increased survival and decreased ECLS use with larger values for all predictors. Importantly, all prenatal values evaluated showed no significant difference between defect size D and NR patients.

Conclusions: This is the largest cohort of LCDH patients and demonstrates that prenatal imaging factors correlate with postnatal outcomes and confirms that patients in the non-repair group are prenatally similar to type D defects.

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