Pediatr Crit Care Med
. 2026 Apr 27.
doi: 10.1097/PCC.0000000000003962. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/42042630/
Impaired Oxygen Delivery Risk Analytics in the 6 Hours Before Extracorporeal Membrane Oxygenation: Single-Center Retrospective Cohort Study in Infants, 2013-2017
Edon J Rabinowitz 1 2 3, Amy Ouyang 3 4, Rejean Guerriero 4, Sarah Bauer Huang 3 4, Kristin Guilliams 1 3 4, Philip R O Payne 5 6, Ahmed S Said 1 3 6
Affiliations Expand
- PMID: 42042630
- DOI: 10.1097/PCC.0000000000003962
Abstract
Objectives: We evaluate the association between pre-extracorporeal membrane oxygenation (ECMO) markers of impaired oxygen delivery, as quantified by the impaired oxygen delivery index (iDo2; Etiometry, Boston, MA) and neurologic outcomes in infants supported on ECMO.
Design: A single-center retrospective cohort study using demographic and clinical data along with iDo2 metrics calculated at 120-minute intervals before ECMO initiation. Primary outcomes included mortality, electroencephalography abnormalities, and head imaging findings. The secondary outcomes included brain MRI abnormalities and Functional Status Score (FSS) at discharge.
Setting: Pediatric ECMO center in North America.
Patients: We included infants younger than 1 year old who were supported on ECMO between 2013 and 2017. We excluded cases with congenital diaphragmatic hernia or postcardiac surgery ECMO.
Interventions: None.
Measurements and main results: We identified 47 infants meeting the inclusion criteria. Median (interquartile range [IQR]) age and weight at ECMO initiation were 16 days (IQR, 6-112 d) and 3.3 kg (IQR, 2.8-4.8 kg). The overall mortality was 26 of 47 (55% [95% CI, 41-69%]). Nonsurvival compared with survival was associated with a greater proportion of patients with congenital heart disease (p = 0.03) and pre-ECMO cardiac arrest (p = 0.006). Time spent above iDo2 thresholds of 25%, 50%, and 75% increased closer to ECMO initiation. Higher iDo2 dose correlated with adverse neurologic outcomes, including electroencephalography abnormalities and abnormal imaging. Last, a logistic regression model for poor outcome (composite of death and FSS), including the time spent above the three iDo2 thresholds at the three time intervals pre-ECMO, showed classification model performance with an area under the receiver operating characteristic curve 0.81 (95% CI, 0.7-0.92; p = 0.0002).
Conclusions: Markers of impaired oxygen delivery, such as iDo2 in the 6 hours before ECMO are associated with subsequent outcome. Incorporation of these metrics into clinical decision-support systems need to be prospectively tested and evaluated.
Keywords: cardiac arrest; decision support; extracorporeal membrane oxygenation; neurologic outcomes; oxygen delivery; pediatric.
Copyright © 2026 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
About The Author
