Dev Cell
. 2026 Mar 11;61(3):460-461.
doi: 10.1016/j.devcel.2026.02.008. https://pubmed.ncbi.nlm.nih.gov/41819068/
MYRF restrains mesothelial plasticity to protect the lung
Rachel Warren 1, Stijn De Langhe 2
Affiliations Expand
- PMID: 41819068
- DOI: 10.1016/j.devcel.2026.02.008
Abstract
In this issue of Developmental Cell, Luna et al.1 identify myelin regulatory factor (MYRF) as a critical determinant of lung mesothelial specification and quiescence. Their study demonstrates that MYRF loss leads to congenital diaphragmatic hernia or a pleuroparenchymal fibroelastosis-like phenotype, revealing the mesothelium as an actively restrained progenitor population.
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