Eur Radiol

. 2025 Nov 24.

doi: 10.1007/s00330-025-12021-1. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/41284033/

Three-dimensional MRI reconstruction of diaphragmatic defects in fetuses with congenital diaphragmatic hernia and mortality prediction

Qiaoli Yang¹, Song Peng², Gongli Chen³, Wei Tang¹, Yali Gao¹, Jialiang Fu¹

Affiliations Expand

PMID: 41284033
DOI: 10.1007/s00330-025-12021-1

Abstract

Objectives: This study aimed to evaluate diaphragmatic defects in fetuses with congenital diaphragmatic hernia (CDH) using three-dimensional (3D) MRI reconstruction for visualization and quantification, and to investigate its correlation with neonatal mortality.

Materials and methods: In this retrospective diagnostic accuracy study, fetuses with prenatally diagnosed left-sided CDH (LCDH) underwent 3D reconstruction of the diaphragm and defect using ITK-SNAP software. The defect-to-diaphragm ratio (DDR) was calculated from measured sizes of the diaphragm and defect. We assessed the correlation between DDR and intraoperative Congenital Diaphragmatic Hernia Study Group (CDHSG) classification, investigated the prognostic value of DDR for neonatal mortality, and compared its predictive performance with that of observed/expected total fetal lung volume (o/e TFLV), percentage of predicted lung volume (PPLV), and observed/expected lung-to-head ratio (o/e LHR).

Results: Ninety fetuses with LCDH underwent diaphragmatic 3D reconstruction and DDR measurement. The prenatal 3D MRI-based CDHSG classification showed substantial agreement with the intraoperative CDHSG classification (weighted kappa = 0.829; p < 0.001). Higher DDR was associated with lower neonatal survival in Kaplan-Meier analysis. The DDR (AUC = 0.919; 95% CI: 0.862-0.977) demonstrated comparable predictive value to other imaging indicators, including o/e TFLV (AUC = 0.905; 95% CI: 0.846-0.965), PPLV (AUC = 0.884; 95% CI: 0.814-0.953), and o/e LHR (AUC = 0.881; 95% CI: 0.812-0.951), in predicting neonatal mortality.

Conclusion: 3D MRI reconstruction enables visualization and quantitative assessment of diaphragmatic defects in fetuses with CDH. DDR is a valuable predictor of neonatal mortality and may aid prenatal risk stratification.

Key points: Question The lack of an objective prenatal method for assessing diaphragmatic defect severity in CDH is addressed through 3D fetal MRI reconstruction. Findings The DDR obtained from 3D MRI correlates with intraoperative CDHSG classification and is a significant predictor of neonatal mortality. Clinical relevance DDR enables prenatal quantification of diaphragmatic defect severity and is associated with neonatal survival, offering a prenatal and objective alternative to postnatal CDHSG classification. These advantages support its utility in risk stratification and perinatal management.

Keywords: Diaphragm; Hernias, Diaphragmatic, Congenital; Imaging, Three-dimensional; Magnetic resonance imaging; Prenatal diagnosis.