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Research: Update on Congenital Diaphragmatic Hernia


Research: Update on Congenital Diaphragmatic Hernia

Anesth Analg. 2019 Jul 17. doi: 10.1213/ANE.0000000000004324. [Epub ahead of print]


Update on Congenital Diaphragmatic Hernia.

Chatterjee D1Ing RJ1Gien J2.

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Congenital diaphragmatic hernia (CDH) is a rare developmental defect of the diaphragm, characterized by herniation of abdominal contents into the chest that results in varying degrees of pulmonary hypoplasia and pulmonary hypertension (PH). Significant advances in the prenatal diagnosis and identification of prognostic factors have resulted in the continued refinement of the approach to fetal therapies for CDH. Postnatally, protocolized approaches to lung-protective ventilation, nutrition, prevention of infection, and early aggressive management of PH have led to improved outcomes in infants with CDH. Advances in our understanding of the associated left ventricular (LV) hypoplasia and myocardial dysfunction in infants with severe CDH have allowed for the optimization of hemodynamics and management of PH. This article provides a comprehensive review of CDH for the anesthesiologist, focusing on the complex pathophysiology, advances in prenatal diagnosis, fetal interventions, and optimal postnatal management of CDH.PMID: 31335403 DOI: 10.1213/ANE.0000000000004324

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