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cdh research Tag

Lung hypoplasia and pulmonary arterial hypertension (PAH) in congenital diaphragmatic hernia (DH) lead to a high  perinatal mortality. Although sustained fetoscopic tracheal occlusion (TO) improves lung development, a major side effect is abnormal pneumocyte differentiation. This study evaluated the potential ability of intra-tracheal retinoic acid...

Congenital diaphragmatic hernia is an anomaly that  appears as a result of abnormal embryological development of the diaphragmatic muscle. It shows up early and has an incidence of 1 in every 2000-3000 live births. It is frequently associated with other congenital anomalies. The mortality is high reaching 40-62% because of...

Objective To assess the longitudinal behavior of Quantitative Lung Index (QLI) for the follow-up of fetuses with congenital diaphragmatic hernia. Study design Retrospective study of fetuses with isolated left congenital diaphragmatic hernia. The fetuses were assessed by ultrasound at different gestational ages and QLI was retrospectively calculated by means of previous lung-to-head...

Congenital diaphragmatic hernia (CDH) has been reported twice in individuals with a clinical diagnosis of Fraser syndrome, a genetic disorder that can be caused by recessive mutations affecting FREM2 and FRAS1. In the extracellular matrix, FREM2 and FRAS1 form a self-stabilizing complex with FREM1, a protein whose deficiency...

Right sided congenital diaphragmatic hernia is seen in about 15% of cases and these patients usually do not have respiratory distress at birth and hence presentation and diagnosis is delayed [1,2]. In right sided defect, most common organ to herniate through the defect is liver. In...