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RESEARCH: Circulating microRNAs are associated with Pulmonary Hypertension and Development of Chronic Lung Disease in Congenital Diaphragmatic Hernia

Congenital diaphragmatic hernia (CDH) is a rare developmental defect of the diaphragm, causing considerable morbidity and mortality1,2. Morphological changes are present from an early developmental stage, consisting of increased muscularization …

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RESEARCH: “Outcomes for thoracoscopic versus open repair of small to moderate congenital diaphragmatic hernias”

Indications for thoracoscopic versus open approaches to repair congenital diaphragmatic hernia (CDH) are unclear as the variability in defect size, disease severity and patient characteristics pose a challenge. Few studies use a …

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RESEARCH: “Fetal tracheal occlusion in mice: a novel transuterine method”

Fetal tracheal occlusion (TO) is an emerging surgical therapy in congenital diaphragmatic hernia that improves the fetal lung growth. Different animal models of congenital diaphragmatic hernia and TO present advantages and disadvantages regarding ethical issues, cost, surgical …

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RESEARCH: “Treprostinil Improves Persistent Pulmonary Hypertension Associated with Congenital Diaphragmatic Hernia”

We conducted a retrospective cohort study of infants with CDH-associated pulmonary hypertension treated with treprostinil from January 2011 to September 2016. Severity of pulmonary hypertension was assessed by echocardiogram and …

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RESEARCH: “Defining outcomes following congenital diaphragmatic hernia using standardised clinical assessment and management plan (SCAMP) methodology within the CDH EURO consortium”

Treatment modalities for neonates born with congenital diaphragmatic hernia (CDH) have greatly improved in recent times with a concomitant increase in survival. In 2008, CDH EURO consortium, a collaboration of …