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CDHi attends British Pediatric Surgical Association’s 2018 Conference

Last week, CDHi’s president spent the week with the British Pediatric Surgical Association at their 2018 conference in Liverpool and was able to see several of our Medical Advisors, meet many new surgeons, and catch up on research coming out of the UK.   CDHi is very excited to become more involved in England and …

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RESEARCH: “Outcomes for thoracoscopic versus open repair of small to moderate congenital diaphragmatic hernias”

Indications for thoracoscopic versus open approaches to repair congenital diaphragmatic hernia (CDH) are unclear as the variability in defect size, disease severity and patient characteristics pose a challenge. Few studies use a patient and disease-matched comparison of techniques. We aimed to compare the clinical outcomes of open versus thoracoscopic repairs of small to moderate sized hernia defects …

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RESEARCH: “Fetal tracheal occlusion in mice: a novel transuterine method”

Fetal tracheal occlusion (TO) is an emerging surgical therapy in congenital diaphragmatic hernia that improves the fetal lung growth. Different animal models of congenital diaphragmatic hernia and TO present advantages and disadvantages regarding ethical issues, cost, surgical difficulty, size, survival rates, and available genetic tools. We developed a minimally invasive murine transuterine TO model, which will be useful in defining how TO …

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VIDEO: Dr. Jay Wilson in “History of Medicine Series: Congenital Diaphragmatic Hernia”

This video is an installment of OPENPediatric’s History of Medicine series, in which they discuss the history of modern medicine with experts from around the globe. In this video, Dr. Jay Wilson, Senior Associate of Surgery and Critical Care at Boston Children’s Hospital, Associate Professor at Harvard Medical School, and one of our proud Medical Advisory Board …

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RESEARCH: “Treprostinil Improves Persistent Pulmonary Hypertension Associated with Congenital Diaphragmatic Hernia”

We conducted a retrospective cohort study of infants with CDH-associated pulmonary hypertension treated with treprostinil from January 2011 to September 2016. Severity of pulmonary hypertension was assessed by echocardiogram and serum B-type natriuretic peptide (BNP) by using time points before initiation and 24 hours, 1 week, and 1 month after treprostinil initiation. Fisher exact tests, …

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RESEARCH: “Defining outcomes following congenital diaphragmatic hernia using standardised clinical assessment and management plan (SCAMP) methodology within the CDH EURO consortium”

Treatment modalities for neonates born with congenital diaphragmatic hernia (CDH) have greatly improved in recent times with a concomitant increase in survival. In 2008, CDH EURO consortium, a collaboration of a large volume of CDH centers in Western Europe, was established with a goal to standardize management and facilitate multicenter research. However, limited knowledge on …

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CDHi Video Interview with YouTube Personality “Q The Nurse”

Rachael Eller, CDH International’s Operations Manager, had the pleasure of being interviewed by Swardiq ‘Q’ Mayanja, aka “Q The Nurse,” at the National Nurse Networking event in Washington DC in April. Q is a nurse, as well as a YouTube personality whose content centers around nursing and the healthcare industry. Watch the video here: https://www.youtube.com/watch?v=g4LspGHatTs  

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RESEARCH: Treprostinil Improves Persistent Pulmonary Hypertension Associated with Congenital Diaphragmatic Hernia

We conducted a retrospective cohort study of infants with CDH-associated pulmonary hypertension treated with treprostinil from January 2011 to September 2016. Severity of pulmonary hypertension was assessed by echocardiogram and serum B-type natriuretic peptide (BNP) by using time points before initiation and 24 hours, 1 week, and 1 month after treprostinil initiation. Fisher exact tests, …

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RESEARCH: Feasibility of non-invasive Neurally adjusted ventilator assist after congenital diaphragmatic hernia repair

The use of neurally adjusted ventilator assist (NAVA) in congenital diaphragmatic hernia (CDH) patients has been historically deemed unwise, since the trigger for breaths is the electromyographic activity of the diaphragmatic muscle. We report on our NAVA experience in CDH patients. Read more HERE.

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Research: “A Case of Incarcerated Traumatic Diaphragmatic Hernia”

Abstract A 74-year-old woman was admitted to our hospital because of back pain and difficulty of breathing, which started the previous night. She had a history of multiple traumas caused by a traffic accident 4 months prior. She was developing a shock but showed no signs of peritonitis. A computed tomography scan showed dilation of …

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Research: “Treatment of rat congenital diaphragmatic hernia with sildenafil and NS-304, selexipag’s active compound, at the pseudoglandular stage improves lung vasculature.”

Patients with congenital diaphragmatic hernia (CDH) often suffer from severe pulmonary hypertension and the choice of current vasodilator therapy is mostly based on trial and error. Since pulmonary vascular abnormalities are already present early during development, we performed a study to modulate these pulmonary vascular changes at an early stage during gestation. Read more HERE.