Int J Artif Organs

. 2021 Feb 18;391398821994113. doi: 10.1177/0391398821994113. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/33596701/

ABO incompatibility and mild factor VIII deficiency in the neonate: Not too much of a problem but a challenge on ECMO

Anna Hofer ¹, Barbara Prandstetter ¹, Markus Bruckner ¹, Gabriele Leithner ²Affiliations expand

• PMID: 33596701
• DOI: 10.1177/0391398821994113

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Abstract

Coagulopathy and bleeding on extracorporeal membrane oxygenation (ECMO) contribute to a worse outcome, and hyperbilirubinemia is an additional threat for newborn babies. We report a case of a newborn boy with congenital diaphragmatic hernia (CDH) associated with ABO incompatibility and an inherited mild hemophilia A. Due to respiratory failure he needed ECMO on his first day of life. During ECMO an exchange transfusion was performed after an extensive hyperbilirubinemia had evolved. Thereafter severe bleeding occurred, and a very low factor VIII level was found causative for that. After factor VIII substitution bleeding was under control and the baby eventually could be weaned from ECMO, underwent corrective surgery, and recovered.

Keywords: ABO incompatibility; ECMO; congenital diaphragmatic hernia; hemophilia A.