Front Pediatr

. 2021 Dec 23;9:740941. doi: 10.3389/fped.2021.740941. eCollection 2021. https://pubmed.ncbi.nlm.nih.gov/35004536/

The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia

Meike Weis ¹, Sosan Burhany ², Alba Perez Ortiz ², Oliver Nowak ³, Svetlana Hetjens ⁴, Katrin Zahn ⁵, Stefan Schoenberg ¹, Thomas Schaible ², Neysan Rafat ²Affiliations expand

• PMID: 35004536
• PMCID: PMC8733701
• DOI: 10.3389/fped.2021.740941

Free PMC article

Abstract

Objective: Valid postnatal prediction parameters for neonates with congenital diaphragmatic hernia (CDH) are lacking, but recently, the chest radiographic thoracic area (CRTA) was proposed to predict survival with high sensitivity. Here, we evaluated whether the CRTA correlated with morbidity and mortality in neonates with CDH and was able to predict these with higher sensitivity and specificity than prenatal observed-to-expected (O/E) lung-to-head ratio (LHR). Methods: In this retrospective cohort study, all neonates with CDH admitted to our institution between 2013 and 2019 were included. The CRTA was measured using the software Horos (V. 3.3.5) and compared with O/E LHR diagnosed by fetal ultrasonography in relation to outcome parameters including survival, extracorporeal membrane oxygenation (ECMO) support, and chronic lung disease (CLD). Results: In this study 255 neonates were included with a survival to discharge of 84%, ECMO support in 46%, and 56% developing a CLD. Multiple regression analysis demonstrated that the CRTA correlates significantly with survival (p = 0.001), ECMO support (p < 0.0001), and development of CLD (p = 0.0193). The CRTA displayed a higher prognostic validity for survival [area under the curve (AUC) = 0.822], ECMO support (AUC = 0.802), and developing a CLD (AUC = 0.855) compared with the O/E LHR. Conclusions: Our data suggest that the postnatal CRTA might be a better prognostic parameter for morbidity and mortality than the prenatal O/E LHR.

Keywords: O/E LHR; chronic lung disease (CLD); congenital diaphragmatic hernia (CDH); extracorporeal membrane oxygenation; neonate; survival.

Copyright © 2021 Weis, Burhany, Perez Ortiz, Nowak, Hetjens, Zahn, Schoenberg, Schaible and Rafat.