J Clin Med
. 2023 Feb 14;12(4):1508.
doi: 10.3390/jcm12041508. https://pubmed.ncbi.nlm.nih.gov/36836043/
Fetal Lung Volume Appears to Predict Respiratory Morbidity in Congenital Diaphragmatic Hernia
Valentine Cerbelle 1, Kévin Le Duc 2 3, Stephanie Lejeune 1, Sébastien Mur 3, Héloise Lerisson 4, Elodie Drumez 5, Rony Sfeir 6, Julien Bigot 4 7 8, Pauline Verpillat 4, Riadh Boukhris 3, Pascal Vaast 9, Clémence Mordacq 1, Caroline Thumerelle 1, Laurent Storme 2 3, Antoine Deschildre 1, Center For Rare Disease Congenital Diaphragmatic Hernia
Affiliations expand
- PMID: 36836043
- PMCID: PMC9961622
- DOI: 10.3390/jcm12041508
Free PMC article
Abstract
Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypoplasia and respiratory morbidity. To assess whether respiratory morbidity during the first 2 years of life in infants with left-sided CDH is associated with fetal lung volume (FLV) evaluated by the observed-to-expected FLV ratio (o/e FLV) on antenatal magnetic resonance imaging (MRI). In this retrospective study, o/e FLV measures were collected. Respiratory morbidity in the first 2 years of life was studied according to two endpoints: treatment with inhaled corticosteroids for >3 consecutive months and hospitalization for any acute respiratory disease. The primary outcome was a favorable progression defined by the absence of either endpoint. Forty-seven patients were included. The median o/e FLV was 39% (interquartile range, 33-49). Sixteen (34%) infants were treated with inhaled corticosteroids and 13 (28%) were hospitalized. The most efficient threshold for a favorable outcome was an o/e FLV ≥ 44% with a sensitivity of 57%, specificity of 79%, negative predictive value of 56%, and positive predictive value of 80%. An o/e FLV ≥ 44% was associated with a favorable outcome in 80% of cases. These data suggest that lung volume measurement on fetal MRI may help to identify children at lower respiratory risk and improve information during pregnancy, patient characterization, decisions about treatment strategy and research, and personalized follow-up.
Keywords: antenatal diagnosis; child; congenital diaphragmatic hernia; fetal lung volume; fetal magnetic resonance imaging; prognostic factor; respiratory morbidity.
