J Perinatol

. 2023 Aug 15.

 doi: 10.1038/s41372-023-01750-0. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/37582931/

Assessment of pulmonary artery size at birth as a prognostic factor in congenital diaphragmatic hernia: results of a multicenter study in Japan

Tadaharu Okazaki ¹, Keita Terui ², Kouji Nagata ³, Masahiro Hayakawa ⁴, Hiroomi Okuyama ⁵, Shoichiro Amari ⁶, Kouji Masumoto ⁷, Masaya Yamoto ⁸, Noboru Inamura ⁹, Katsuaki Toyoshima ¹⁰, Taizo Furukawa ¹¹, Manabu Okawada ¹², Akiko Yokoi ¹³, Yuki Koike ¹⁴, Shuko Nojiri ¹⁵, Yuji Nishizaki ¹⁶, Naotake Yanagisawa ¹⁵, Noriaki Usui ¹⁷

Affiliations expand

• PMID: 37582931
• DOI: 10.1038/s41372-023-01750-0

Abstract

Objective: To assess the reliability of pulmonary artery (PA) parameters as a prognostic marker in neonates with isolated left-sided congenital diaphragmatic hernia (IL-CDH).

Study design: A retrospective cohort study conducted by the Japanese CDH Study Group (JCDHSG).

Results: 323 IL-CDH patients registered with the JCDHSG were included. 272 patients survived to 90 days of age. Right PA (RPA) and left PA (LPA) diameters and pulmonary artery index (PAIndex) at birth were significantly larger in survivors. The cutoff values of RPA and LPA diameters and PAIndex for survival up to 90 days were 3.2 mm, 2.8 mm and 83.7, respectively, and logistic regression analysis showed that these were significantly related to survival. Multiple logistic regression analysis showed that both the PA parameters and liver herniation were significantly related to survival.

Conclusions: The three PA parameters at birth can predict clinical outcomes and are considered as independent risk factors of liver herniation.

© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.