Semin Pediatr Surg
. 2024 Jul 2;33(4):151439.
doi: 10.1016/j.sempedsurg.2024.151439. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/38986241/
Ventilator strategies in congenital diaphragmatic hernia
Shaun M Kunisaki 1, Suneetha Desiraju 2, Michelle J Yang 3, Satyan Lakshminrusimha 4, Bradley A Yoder 3
Affiliations expand
- PMID: 38986241
- DOI: 10.1016/j.sempedsurg.2024.151439
Abstract
This review focuses on contemporary mechanical ventilator practices used in the initial management of neonates born with congenital diaphragmatic hernia (CDH). Both conventional and non-conventional ventilation modes in CDH are reviewed. Special emphasis is placed on the rationale for gentle ventilation and the current evidence-based clinical practice guidelines that are recommended for supporting these fragile infants. The interplay between CDH lung hypoplasia and other key cardiopulmonary elements of the disease, namely a reduced pulmonary vascular bed, abnormal pulmonary vascular remodeling, and left ventricular hypoplasia, are discussed. Finally, we provide insights into future avenues for mechanical ventilator research in CDH.
Keywords: Congenital diaphragmatic hernia; High-frequency jet ventilator; High-frequency oscillatory ventilator; Lung hypoplasia; Mechanical ventilator.
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