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                            Title & authors                            Abstract                                        Conflict of interest statement                                    Similar articles                                Publication types                                            Related information                            LinkOut – more resources                

Practice GuidelineArch Pediatr

. 2024 Jul 13:S0929-693X(24)00086-1.

 doi: 10.1016/j.arcped.2024.03.006. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/39003158/

Indications for extensively hydrolyzed cow’s milk protein in the neonatal period

Virginie Rigourd ¹, Alice Heneau ², Anne-Laure Virlouvet ², Aurelie Basset ², Estelle Herry ², Bénedicte Jaquemet ³, Marc Bellaiche ⁴, Alexandre Lapillonne ⁵, Patrick Tounian ⁶

Affiliations expand

• PMID: 39003158
• DOI: 10.1016/j.arcped.2024.03.006

Abstract

A large proportion of prescriptions for extensively hydrolyzed cow’s milk protein (CMP) in newborns are not based on any scientific data justifying the indication. Many of these prescriptions are old habits or are based on incomplete data. The aim of this article is to analyze these practices and propose recommendations. The following points are covered: (a) indications for extensively hydrolyzed formula based on studies demonstrating their benefits in these situations-newborns with a proven allergy to CMP and occasional prescription of supplements to breastfeeding; (b) possible indications not based on a high level of evidence-re-initiation of feeding due to necrotizing enterocolitis, short bowel syndrome, re-initiation of feeding of newborns following intestinal surgery, and laparoschisis if neither the mother’s own milk nor milk from a lactarium is available; (c) unjustified indications-newborns at risk of atopy, prematurity, severe neurological pathologies, newborns who are hemodynamically unstable and/or have congenital cardiopathy, neonatal hypoxic-ischemic encephalopathy treated with hypothermia, and newborns with esophageal atresia or diaphragmatic hernia. By following this classification, the prescriber will be guided to use the milk best suited to the pathology, bearing in mind that each situation must be adapted individually and the tolerance and effectiveness of the food reassessed from a nutritional and functional point of view.

Keywords: Breast milk supplement; Breastfeeding; Cow’s milk protein allergy; Extensively hydrolyzed cow’s milk protein; Lactarium milk.

Copyright © 2024 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.