Congenital diaphragmatic hernia is an anomaly that 
appears as a result of abnormal embryological development
of the diaphragmatic muscle. It shows up early and has an
incidence of 1 in every 2000-3000 live births. It is frequently
associated with other congenital anomalies. The mortality is
high reaching 40-62% because of respiratory failure
secondary to pulmonary hypoplasia. Of current interest is the
role that retinoic acid plays in different biological processes,
including embryogenesis and pulmonary development.
Retinoic acid signalling pathway was identified as an
important factor in the diaphragmatic muscle development.
Read more here: https://www.researchgate.net/publication/323390755
