Neonatology

. 2024 Nov 6:1-8.

 doi: 10.1159/000541385. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/39504949/

Association between Time with Open Ductus Arteriosus and Outcomes in Congenital Diaphragmatic Hernia

Srirupa Hari Gopal ¹, Robert Tillman ², James D Hammond Ii ³, Joseph L Hagan ¹, Sharada H Gowda ¹, Nidhy P Varghese ⁴, Caraciolo J Fernandes ¹

Affiliations Expand

• PMID: 39504949
• DOI: 10.1159/000541385

Abstract

Introduction: While a patent ductus arteriosus (PDA) helps offload the right ventricle in the acute congenital diaphragmatic hernia (CDH)-associated pulmonary hypertension, its role on long-term outcomes in CDH has not been investigated. Our objective was to examine associations of the PDA with long-term clinical outcomes in CDH.

Methods: A single-center retrospective descriptive study of 122 CDH patients dichotomized by duration with PDA, as ≤14 versus >14 postnatal days (PND) and ≤30 versus >30 PND. Fisher’s exact test, Wilcoxon rank-sum test, and multiple linear and logistic regression analyses were used for analyses.

Results: In unadjusted and adjusted for CDH severity comparisons, patients with PDA >14 PND and >30 PND had a higher risk of death, longer length of stay, mechanical ventilation duration, and need for tracheostomy, diuretics, and PH medications at discharge.

Conclusion: A PDA beyond the newborn period is associated with adverse outcomes in infants with CDH.

Keywords: Congenital diaphragmatic hernia; Ductus arteriosus; Neonatology; Pulmonary hypertension.

© 2024 S. Karger AG, Basel.