J Pediatr Surg

. 2023 Mar 18;S0022-3468(23)00197-5.

 doi: 10.1016/j.jpedsurg.2023.03.011. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/37032194/

Intraoperative Transpyloric Tube Insertion for Congenital Diaphragmatic Hernia: Analysis of Japanese Study Group Data

Hidehiko Maruyama ¹, Shoichiro Amari ², Yutaka Kanamori ³, Masahiro Hayakawa ⁴, Kouji Nagata ⁵, Yuta Yazaki ⁶, Yoshihiko Taniyama ⁷, Kazunori Masahata ⁸, Masaya Yamoto ⁹, Keita Terui ¹⁰, Kiyokazu Kim ¹¹, Yuhki Koike ¹², Tadaharu Okazaki ¹³, Noboru Inamura ¹⁴, Noriaki Usui ¹⁵; Japanese Congenital Diaphragmatic Hernia Study Group

Affiliations expand

• PMID: 37032194
• DOI: 10.1016/j.jpedsurg.2023.03.011

Abstract

Background: Congenital diaphragmatic hernia (CDH) is a severe congenital disease. Some CDH infants suffer from gastro-esophageal reflux disease (GERD), even after surgical correction of gastric position. A transpyloric tube (TPT) is inserted into CDH patients under direct observation intraoperatively in some hospitals in Japan to establish early enteral feeding. This strategy avoids gastric expansion to maintain a better respiratory condition. However, it is unclear whether the strategy has a secure effect for patient prognosis. This study aimed to evaluate the effectiveness of intraoperative TPT insertion on enteral feeding and postoperative weight gain.

Methods: The Japanese CDH Study Group database was used to identify infants with CDH born between 2011 and 2016, who were then divided into two groups: the TPT group and gastric tube (GT) group. In the TPT group, infants underwent intraoperative TPT insertion; postoperative insertion/extraction of TPT was irrelevant to the analysis. Weight growth velocity (WGV) was calculated using the exponential model. Subgroup analysis was performed using Kitano’s gastric position classification.

Results: We analyzed 204 infants, of which 99 and 105 were in the TPT and GT groups, respectively. Enteral nutrition (EN) in the TPT and GT groups was 52 ± 39 and 44 ± 41 kcal/kg/day (p = 0.17) at age 14 days (EN14), respectively, and 83 ± 40 and 78 ± 45 kcal/kg/day (p = 0.46) at age 21 days (EN21), respectively. WGV30 (WGV from day 0 to day 30) in the TPT and GT groups was 2.3 ± 3.0 and 2.8 ± 3.8 g/kg/day (p = 0.30), respectively, and WGV60 (WGV from day 0 to day 60) was 5.1 ± 2.3 and 6.0 ± 2.5 g/kg/day (p = 0.03), respectively. In infants with Kitano’s Grade 2 + 3, EN14 in the TPT and GT groups was 38 ± 35 and 29 ± 35 kcal/kg/day (p = 0.24), respectively, EN21 was 73 ± 40 and 58 ± 45 kcal/kg/day (p = 0.13), respectively, WGV30 was 2.3 ± 3.2 and 2.0 ± 4.3 g/kg/day (p = 0.76), respectively, and WGV60 was 4.6 ± 2.3 and 5.2 ± 2.3 g/kg/day (p = 0.30), respectively.

Conclusion: Intraoperative TPT insertion did not improve nutritional intake and WGV30. WGV60 in TPT was less than that in GT. In Grade 2 + 3 subgroup analysis, TPT also had no advantage. We could not recommend routine TPT insertion at surgery.

Level of evidence: III.

Keywords: Congenital diaphragmatic hernia; Gastric tube; Transpyloric tube; Weight growth velocity.

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