Semin Fetal Neonatal Med
. 2022 Nov 17;101407.
doi: 10.1016/j.siny.2022.101407. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/36411199/
Management of the CDH patient on ECLS
Alice Martino 1, Gianluca Lista 2, Yigit S Guner 3
Affiliations expand
- PMID: 36411199
- DOI: 10.1016/j.siny.2022.101407
Abstract
Congenital diaphragmatic hernia (CDH) is the most common indication for respiratory extracorporeal life support (ECLS) in neonates. The survival rate of CDH neonates treated with ECLS is 50%, and this figure has remained relatively stable over the last few decades. This is likely because the current population of CDH neonates who require ECLS have a higher risk profile [1]. The management of neonates with CDH has evolved over time to emphasize postnatal stabilization, gentle ventilation, and multi-modal treatment of pulmonary hypertension. In order to minimize practice variation, many centers have adopted CDH-specific clinical practice guidelines, however care is not standardized between different centers and outcomes vary [3]. The purpose of this review is to summarize our current understanding of issues central to the care of neonates with CDH treated with ECLS and specifically highlight how the use of the Extracorporeal Life Support Organization (ELSO) data have added to our understanding of CDH.
Keywords: CDH; ECLS.
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