Early Hum Dev
. 2023 Dec 9:188:105914.
doi: 10.1016/j.earlhumdev.2023.105914. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/38103310/
Prevalence and patterns of executive function, adaptive function, and behavioral outcomes in preschool and school age children with congenital diaphragmatic hernia
Enrico Danzer 1, Jane E Schreiber 2, Casey Hoffman 2, Leny Mathew 2, Sabrina J Flohr 2, Elizabeth Eppley 2, Sierra D Land 2, Lisa Herkert 2, Natalie E Rintoul 2, N Scott Adzick 2, Holly L Hedrick 2
Affiliations expand
- PMID: 38103310
- DOI: 10.1016/j.earlhumdev.2023.105914
Abstract
Background: Executive function, adaptive function, and behavioral outcomes in congenital diaphragmatic hernia (CDH) survivors have not been well studied.
Aim: To evaluate executive and neurobehavioral dysfunction in preschool and early school-aged children with CDH.
Study design: Retrospective cohort study.
Subjects: All eligible CDH survivors ages 3 to 7 years enrolled in our follow-up program between February 2020 and February 2021.
Outcome measures: The Behavior Rating Inventory of Executive Function (BRIEF), the Adaptive Behavior Assessment System, 2nd Edition (ABAS-II), and the Child Behavior Checklist (CBCL) were used to assess functional and behavioral outcomes. Summary scores were compared to standard population norms.
Results: A total of 100 patients were enrolled during the study period. Of those, 73 parents completed at least one of the questionnaires, resulting in completion of the BRIEF, ABAS-II, and CBCL for 63, 68, and 63 patients, respectively. Preschool children had normal executive function (BRIEF-P) while global executive composite (P = 0.012) and the emotional regulation index (P = 0.010) for school age patients (BRIEF-2) were worse. CDH survivors had favorable adaptive functioning (ABAS-II). Mean CBCL scores for preschool attention problems (P = 0.018), school age attention problems (P = 0.001), and attention deficits hyperactivity problems (P = 0.027) were significantly worse. Prematurity, surrogate markers of disease severity, non-white race, and public insurance status were associated with worse neurobehavioral dysfunction in bivariable analysis.
Conclusions: The majority of preschool and school age CDH survivors have age-appropriate executive, adaptive and behavioral functioning. CDH survivors, however, have lower executive function and attention scores compared with the general population.
Keywords: Congenital diaphragmatic hernia; Disability; Executive dysfunction; Neurobehavioral delays; Neuropsychology.
Copyright © 2023. Published by Elsevier B.V.
