Front Pediatr

. 2022 Feb 9;10:823180. doi: 10.3389/fped.2022.823180. eCollection 2022. https://pubmed.ncbi.nlm.nih.gov/35223699/

Recurrence of Congenital Diaphragmatic Hernia: Risk Factors, Management, and Future Perspectives

Francesco Macchini ¹, Genny Raffaeli ^2 3, Ilaria Amodeo ², Martina Ichino ¹, José Luis Encinas ⁴, Leopoldo Martinez ⁴, Lucas Wessel ⁵, Giacomo Cavallaro ²Affiliations expand

• PMID: 35223699
• PMCID: PMC8864119
• DOI: 10.3389/fped.2022.823180

Free PMC article

Abstract

Recurrence is one of the most common surgical complications in Congenital Diaphragmatic Hernia (CDH). It could remain clinically silent for a long time or present as an acute complication week, months, or even years after the primary surgery. Several risk factors have been identified so far. An extended diaphragmatic defect represents one of the leading independent risk factors, together with indirect signs of large defect such as the liver position related to the diaphragm and the use of the prosthetic patch and with the use of a minimally invasive surgical (MIS) approach. However, the exact contribution of each factor and the overall risk of recurrence during the life span still need to be fully understood. This mini-review aims to give an overview of the current knowledge regarding CDH recurrence, focusing on predisposing factors, clinical presentation, management and follow-up of high-risk patients, and future perspectives.

Keywords: FETO; congenital diaphragmatic hernia; hernia recurrence; minimally invasive surgery; mortality; prosthetic patch; pulmonary hypertension.

Copyright © 2022 Macchini, Raffaeli, Amodeo, Ichino, Encinas, Martinez, Wessel and Cavallaro.