Fetal Diagn Ther

. 2021 Mar 23;1-7. doi: 10.1159/000512491. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/33756472/

Reproducibility of Lung and Liver Volume Measurements on Fetal Magnetic Resonance Imaging in Left-Sided Congenital Diaphragmatic Hernia

Amy B Kolbe ¹, Eniola R Ibirogba ², Kristen B Thomas ¹, Nathan C Hull ¹, Paul G Thacker ¹, Matthew Hathcock ², Haleh Sangi-Haghpeykar ³, Rodrigo Ruano ⁴Affiliations expand

• PMID: 33756472
• DOI: 10.1159/000512491

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Abstract

Introduction: Congenital diaphragmatic hernia (CDH) affects 1 in 3,000 live births and is associated with significant morbidity and mortality.

Methods: A review of fetal magnetic resonance imaging (MRI) examinations was performed for fetuses with left CDH and normal lung controls. Image review and manual tracings were performed by 4 pediatric radiologists; right and left lung volumes in the coronal and axial planes as well as liver volume above and below the diaphragm in the coronal plane were measured. Intra- and interreviewer reproducibility was assessed using intraclass correlation coefficient (ICC) and Bland-Altman analysis.

Results: Excellent intra- and interreviewer reproducibility of the right and left lung volume measurements was observed in both axial planes (interreviewer ICC: right lung: 0.97, 95% CI: 0.95-0.99; left lung: 0.97, 95% CI: 0.95-0.98) and coronal planes (interreviewer ICC: right lung: 0.97, 95% CI: 0.95-0.98; left lung: 0.96, 95% CI: 0.93-0.98). Moderate-to-good interreviewer reproducibility was observed for liver volume above the diaphragm (ICC 0.7, 95% CI: 0.59-0.81). Liver volume below the diaphragm had a good-to-excellent interreviewer reproducibility (ICC 0.88, 95% CI: 9.82-0.93).

Conclusions: The present study demonstrated an excellent intra- and interreviewer reproducibility of MRI lung volume measurements and good-to-moderate inter- and intrareviewer reproducibility of liver volume measurements after standardization of the methods at our fetal center.

Keywords: Congenital diaphragmatic hernia; Fetal magnetic resonance imaging; Fetal therapy; Prenatal diagnosis; Pulmonary hypoplasia.

© 2021 S. Karger AG, Basel.