BJOG

. 2024 May 15.

 doi: 10.1111/1471-0528.17836. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/38747110/

Self-reported respiratory and gastrointestinal outcomes in children with isolated congenital diaphragmatic hernia: A prospective multicentre study

Mary Patrice Eastwood ^1 2, Lennart Van der Veeken ¹, Luc Joyeux ¹, Laura Salazar ², Juan Otano ², Rashmi d’Souza ³, Martin Sidler ⁴, Francesca Maria Russo ¹, Jordi Prat ⁵, Paolo de Coppi ^1 4, Eduard Gratacós ², Jan Deprest ^1 3 6

Affiliations expand

• PMID: 38747110
• DOI: 10.1111/1471-0528.17836

Abstract

Objective: To evaluate medium-term self-reported respiratory and gastrointestinal (GI) outcomes in children with congenital diaphragmatic hernia (CDH).

Design: Self-reported respiratory and GI outcomes correlated with prenatal severity indicators.

Setting: Prospective study at three fetal medicine units.

Population: Families of children prenatally diagnosed with isolated, left-sided CDH surviving for >1 year.

Methods: Families received validated questionnaires for GI outcomes (Infant Gastroesophageal Reflux Questionnaire Revised, I-GERQ-R, for infants aged <2 years, or Paediatric Gastro-oesophageal Symptom and Quality of Life Questionnaire, PGSQ, for children aged aged 2-8 years or >9 years) and respiratory outcomes (preschool respiratory outcome questionnaire, for children aged ≤5 years, or the International Study of Asthma and Allergies in Childhood asthma questionnaire, for children aged 6-8 years or ≥9 years). Prenatal data collected from the medical records included lung size (percentage observed/expected lung-to-head ratio, O/E LHR %), liver position, fetal endoluminal tracheal occlusion (FETO) gestational age (GA) at delivery, and perinatal data included birthweight, location, patch repair and respiratory support.

Main outcome measures: The GI and respiratory scores were correlated with O/E LHR using linear and logistic regression models. Univariate analysis was used to evaluate associations with perinatal variables.

Results: We obtained 142 responses from 342 families (representing a response rate of 45%). The baseline characteristics of participants and non-participants were comparable. No correlations between perinatal variables and respiratory or GI scores were identified. Children aged ≤5 years with lower O/E LHR values reported higher respiratory scores (P = 0.0175); this finding was not reported in older children. Overall, the children who underwent FETO (n = 51) had GI (P = 0.290) and respiratory (P = 0.052) scores that were comparable with those of children who were expectantly managed.

Conclusions: Families and children with prenatally diagnosed CDH reported fewer respiratory symptoms with increasing age. There was no correlation between O/E LHR or the use of FETO and self-reported outcomes.

Keywords: congenital diaphragmatic hernia; fetal endoscopic tracheal occlusion; gastrointestinal outcomes; respiratory outcomes.

© 2024 John Wiley & Sons Ltd.