J Perinat Med. 2019 Oct 11. pii: /j/jpme.ahead-of-print/jpm-2019-0144/jpm-2019-0144.xml. doi: 10.1515/jpm-2019-0144. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/31603859
The use of atosiban prolongs pregnancy in patients treated with fetoscopic endotracheal occlusion (FETO).
Kosinski P1, Luterek K2, Lipa M2, Wielgos M2.
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11Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza 1/3, 02-015 Warsaw, Poland, Tel.: +48 22 583 03 01, Fax: +48 22 583 03 02.21Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.
Abstract
Objective To evaluate the impact of atosiban as a tocolytic agent in patients treated with the fetoscopic endotracheal occlusion (FETO) procedure due to congenital diaphragmatic hernia (CDH). As premature birth after fetoscopy remains a serious concern, an effort to reduce prematurity is required. Methods A total of 43 patients with severe CDH treated with FETO were enrolled in this study. The study group consisted of 22 patients who received atosiban during the FETO procedure and a control group of 21 patients who did not receive atosiban during the FETO procedure. Demographic data, gestational age (GA) at delivery, cervical length and GA at premature rupture of membranes (PROM) were evaluated. Results The GA at delivery was significantly different between the two groups studied. The median GA at delivery was 32.6 and 34.5 weeks in the no-atosiban vs. atosiban groups, respectively (P = 0.013). The median cervical length was 29.9 and 31.2 mm for the no-atosiban and atosiban groups, respectively, and was not statistically significant (P = 0.28). There were no significant correlations between groups for the occurrence of PROM, GA at the time of PROM, duration of the procedures, parity, maternal body mass index (BMI) or age. In the univariate linear regression model, the only factor independently associated with GA at delivery was the use of atosiban during FETO procedures (β = 0.375; P < 0.013). Conclusion In cases of severe CDH treated with FETO, the use of atosiban as a tocolytic agent during the procedure prolonged pregnancy by 2 weeks. Cervical length, duration of FETO or maternal characteristics were not associated with GA at delivery.
KEYWORDS:
atosiban; congenital diaphragmatic hernia; endotracheal occlusion; fetoscopy; preterm delivery; preterm labor; tocolysisPMID: 31603859 DOI: 10.1515/jpm-2019-0144
