Pediatr Cardiol

. 2023 Jul 13.

 doi: 10.1007/s00246-023-03233-7. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/37442851/

Transcatheter Ductus Arteriosus Stenting for Acute Pediatric Pulmonary Arterial Hypertension is Associated with Improved Right Ventricular Echocardiography Strain

Jason S Kerstein ^1 2, Eleonore Valencia ^3 4, Shane Collins ³, Alessandra M Ferraro ³, David M Harrild ^3 4, Kimberlee Gauvreau ^3 4, Ryan Callahan ^3 4 5, Mary P Mullen ^3 4

Affiliations expand

• PMID: 37442851
• DOI: 10.1007/s00246-023-03233-7

Abstract

Background: Interventional therapies for severe pulmonary arterial hypertension (PAH) can provide right ventricular (RV) decompression and preserve cardiac output. Transcatheter stent placement in a residual ductus arteriosus (PDA) is one potentially effective option in critically ill infants and young children with PAH. We sought to assess recovery of RV function by echocardiographic strain in infants and young children following PDA stenting for acute PAH.

Methods: Retrospective review of patients < 2 years old who underwent PDA stenting for acute PAH. Clinical data were abstracted from the electronic medical record. RV strain (both total and free wall components) was assessed from echocardiographic images at baseline and 3, 6, and 12 months post-intervention, as well as at last echocardiogram.

Results: Nine patients underwent attempted ductal stenting for PAH. The median age at intervention was 38 days and median weight 3.7 kg. One-third (3of 9) of patients had PAH associated with a congenital diaphragmatic hernia. PDA stents were successfully deployed in eight patients. Mean RV total strain was – 14.9 ± 5.6% at baseline and improved to – 23.8 ± 2.2% at 6 months post-procedure (p < 0.001). Mean free wall RV strain was – 19.5 ± 5.4% at baseline and improved to – 27.7 ± 4.1% at 6 months (p = 0.002). Five patients survived to discharge, and four patients survived 1 year post-discharge.

Conclusion: PDA stenting for severe, acute PAH can improve RV function as assessed by strain echocardiography. The quantitative improvement is more prominent in the first 6 months post-procedure and stabilizes thereafter.

Keywords: Patent ductus arteriosus; Pediatric cardiology; Pulmonary arterial hypertension; Right ventricular function; Right ventricular strain.

© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.