Cureus

. 2024 Jul 18;16(7):e64804.

 doi: 10.7759/cureus.64804. eCollection 2024 Jul. https://pubmed.ncbi.nlm.nih.gov/39156276/

Beyond Bronchopulmonary Dysplasia: A Comprehensive Review of Chronic Lung Diseases in Neonates

Khaled El-Atawi ¹, Muzafar Gani Abdul Wahab ², Jubara Alallah ^3 4, Mohammed F Osman ⁵, Moustafa Hassan ⁶, Zohra Siwji ⁵, Maysa Saleh ⁷

Affiliations Expand

• PMID: 39156276
• PMCID: PMC11329945
• DOI: 10.7759/cureus.64804

Abstract

In neonates, pulmonary diseases such as bronchopulmonary dysplasia and other chronic lung diseases (CLDs) pose significant challenges due to their complexity and high degree of morbidity and mortality. This review discusses the etiology, pathophysiology, clinical presentation, and diagnostic criteria for these conditions, as well as current management strategies. The review also highlights recent advancements in understanding the pathophysiology of these diseases and evolving strategies for their management, including gene therapy and stem cell treatments. We emphasize how supportive care is useful in managing these diseases and underscore the importance of a multidisciplinary approach. Notably, we discuss the emerging role of personalized medicine, enabled by advances in genomics and precision therapeutics, in tailoring therapy according to an individual’s genetic, biochemical, and lifestyle factors. We conclude with a discussion on future directions in research and treatment, emphasizing the importance of furthering our understanding of these conditions, improving diagnostic criteria, and exploring targeted treatment modalities. The review underscores the need for multicentric and longitudinal studies to improve preventative strategies and better understand long-term outcomes. Ultimately, a comprehensive, innovative, and patient-centered approach can enhance the quality of care and outcomes for neonates with CLDs.

Keywords: bronchopulmonary dysplasia (bpd); chronic lung diseases in neonates; congenital diaphragmatic hernia (cdh); neonates; pulmonary hypoplasia.

Copyright © 2024, El-Atawi et al.