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Research: Cellular Origin(s) of Congenital Diaphragmatic Hernia

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Research: Cellular Origin(s) of Congenital Diaphragmatic Hernia

Front Pediatr

. 2021 Nov 30;9:804496. doi: 10.3389/fped.2021.804496. eCollection 2021. https://pubmed.ncbi.nlm.nih.gov/34917566/

Cellular Origin(s) of Congenital Diaphragmatic Hernia

Gabriëla G Edel 1 2Gerben Schaaf 3 4 5Rene M H Wijnen 1Dick Tibboel 1Gabrielle Kardon 6Robbert J Rottier 1 2Affiliations expand

Free PMC article

Abstract

Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research.

Keywords: congenital diaphragmatic hernia (CDH); diaphragm; mesothelium; perivascular cells; pleuroperitoneal folds.

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