Research: [Characteristics and Outcome of Neonates With Postnatally Diagnosed Congenital Diaphragmatic Hernia]

Z Geburtshilfe Neonatol

. 2023 Dec 15.

 doi: 10.1055/a-2198-8950. Online ahead of print.

[Characteristics and Outcome of Neonates With Postnatally Diagnosed Congenital Diaphragmatic Hernia]

[Article in German]

Bartolomeo B L Bo 1Lotte Lemloh 1Lennart Hale 1Andreas Heydweiller 2Brigitte Strizek 3Charlotte Bendixen 2Lukas Schroeder 1Andreas Mueller 1Florian Kipfmueller 1

Affiliations expand

Abstract in English, German

Introduction: Congenital diaphragmatic hernia (CDH) is one of the most severe neonatal malformations with a mortality of 20-35%. Currently, the rate of prenatally recognized CDHs is 60-80%. This study investigated the characteristics and outcome data of children with prenatally unrecognized CDH.

Methods: Postnatally diagnosed CDH newborns treated at the University Hospital Bonn between 2012 and 2021 were included. Treatment and outcome data were compared according to type of maternity hospital, Apgar values, and between prenatally and postnatally diagnosed CDH.

Results: Of 244 CDH newborns, 22 were included. Comparison for birth in a facility with vs. without pediatric care showed for mortality: 9% vs. 27%, p=0.478; ECMO rate: 9% vs. 36%, p=0.300; age at diagnosis: 84 vs. 129 min, p=0.049; time between intubation and diagnosis: 20 vs. 86 min, p=0.019. Newborns in the second group showed significantly worse values for pH and pCO2. Furthermore, there was a tendency for higher mortality and ECMO rates in children with an Apgar score<7 vs.≥7. Children diagnosed postnatally were significantly more likely to have moderate or severe PH and tended to have cardiac dysfunction more often than those diagnosed prenatally.

Discussion: In our cohort, ca. one in 10 newborns received a postnatal CDH diagnosis. Birth in a facility without pediatric care is associated with later diagnosis, which may favor hypercapnia/acidosis and more severe pulm.

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