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Research: Clinical outcomes and protocol for the management of isolated congenital diaphragmatic hernia based on our prenatal risk stratification system.

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Research: Clinical outcomes and protocol for the management of isolated congenital diaphragmatic hernia based on our prenatal risk stratification system.

J Pediatr Surg. 2019 Nov 28. pii: S0022-3468(19)30755-9. doi: 10.1016/j.jpedsurg.2019.10.020. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/31864663

Clinical outcomes and protocol for the management of isolated congenital diaphragmatic hernia based on our prenatal risk stratification system.

Masahata K1Usui N2Shimizu Y3Takeuchi M3Sasahara J4Mochizuki N5Tachibana K6Abe T2Yamamichi T2Soh H2.

Author information

Abstract

BACKGROUND/PURPOSE:

The aim of this study was to evaluate our prenatal risk stratification system for risk-adjusted management in fetuses with isolated congenital diaphragmatic hernia (CDH).

METHODS:

Ninety-four infants prenatally diagnosed with isolated CDH treated between 1998 and 2017 at our institution were included in this retrospective single-center cohort study.

RESULTS:

The patients were prenatally classified into four risk groups: Group A (n = 54), which consisted of infants with neither liver-up nor a contralateral lung-to-thorax transverse area (L/T) ratio <0.08. The infants in group A were divided into two subgroups: Group A-1 (n = 24) consisted of mild conditions; and Group A-2 (n = 30) consisted of severe conditions; Group B (n = 23), which consisted of infants with either liver-up or L/T ratio <0.08; and Group C (n = 17), which consisted of infants with both liver-up and L/T ratio <0.08. The rates of survival to discharge in Groups A-1, A-2, B, and C were 100.0%, 100.0%, 87.0%, and 58.8%, respectively. The rates of intact discharge were 91.7%, 90.0%, 52.1%, and 23.5%, respectively.

CONCLUSIONS:

Our prenatal risk stratification system demonstrated a significant difference in the severity of postnatal status and clinical outcomes between the groups.

STUDY TYPE:

Case Series, Retrospective Review.

LEVELS OF EVIDENCE:

LEVEL IV.

Copyright © 2019 Elsevier Inc. All rights reserved.

KEYWORDS:

Congenital diaphragmatic hernia; Prenatal diagnosis; Prognostic classification; Risk stratificationPMID: 31864663 DOI: 10.1016/j.jpedsurg.2019.10.020

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