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Research: Combination of PGE1 and Pulmonary Vasodilator Therapy in Managing a Challenging Case of Severe PAH Secondary to CDH.

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Research: Combination of PGE1 and Pulmonary Vasodilator Therapy in Managing a Challenging Case of Severe PAH Secondary to CDH.

World J Pediatr Congenit Heart Surg. 2020 Jul;11(4):525-527. doi: 10.1177/2150135120912678. https://pmlegacy.ncbi.nlm.nih.gov/pubmed/32645788

Combination of PGE1 and Pulmonary Vasodilator Therapy in Managing a Challenging Case of Severe PAH Secondary to CDH.

Aljohani OA1,2Rao R1,2Mackie D3Haldeman S1Karamlou T4.

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Abstract

Congenital diaphragmatic hernia (CDH) is a rare disease, which affects 1 in 2,500 newborns. Congenital diaphragmatic hernia can interfere with the normal development of the pulmonary parenchyma and vascular bed, and in severe cases, it can lead to the development of severe pulmonary arterial hypertension (PAH) and right ventricular failure. We present a neonate with CDH who developed severe PAH and right ventricular dysfunction and was managed with a unique strategy combining venoarterial extracorporeal membrane oxygenation, prostaglandin E1, and a variety of PAH therapies.PMID: 32645788 DOI: 10.1177/2150135120912678

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