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Research: Detection rates of a national fetal anomaly screening programme: a national cohort study

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Research: Detection rates of a national fetal anomaly screening programme: a national cohort study

BJOG

. 2022 Aug 29.

 doi: 10.1111/1471-0528.17287. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/36054171/

Detection rates of a national fetal anomaly screening programme: a national cohort study

Nicholas Aldridge 1Pranav Pandya 2Judith Rankin 3Nicola Miller 1Jennifer Broughan 1Nadia Permalloo 4Annette McHugh 5Sarah Stevens 1

Affiliations expand

Abstract

Objective: Measure condition-specific detection rates for 14 physical conditions screened for by the NHS fetal anomaly screening programme (FASP) fetal anomaly (FA) ultrasound scan.

Design: Retrospective audit of 12,694 diagnoses across a three-year national cohort.

Setting: All English NHS and crown dependency hospital trusts providing maternity services.

Population: Pregnancies booked for maternity services with an expected date of delivery between 1 April 2017 to 31 March 2020 and at least one diagnosis of a condition screened for by FASP.

Methods: Active multi-source ascertainment, linkage, audit, and validation of clinical information to identify the subset of diagnoses meeting the condition-specific positivity threshold for the FA scan.

Main outcome measure: The accuracy of the FA scan compared to diagnostic reference standards.

Results: FA scan detection rates: anencephaly 96.3% (95% CI: 81.7-99.3%) , atrioventricular septal defect: 69.2% (65.8-72.4%), bilateral renal agenesis: 98.7% (95.4-99.6%), cleft lip: 89.5% (87.8-90.9%), congenital diaphragmatic hernia: 60.8% (56.5-65%) , Edwards’ syndrome: 73.8% (67.5-79.3%), exomphalos: 59.4% (49.4-68.7%), gastroschisis: 88.6% (79-94.1%), hypoplastic left heart syndrome: 92.7% (90-94.8%), lethal skeletal dysplasia: 93.2% (88.6-96%), Patau’s syndrome: 82.3% (72.4-89.1%), spina bifida: 93.8% (91.8-95.3%), tetralogy of Fallot: 75.4% (72.1-78.4%), transposition of the great arteries: 84.9% (81.7-87.5%).

Conclusions: The performance of the FA scan is above the expectations set in 2010 for most conditions. For the remaining conditions, the majority of fetuses and babies are detected prior to the FA scan.

Keywords: Antenatal; congenital anomaly; fetal; radiology; screening; sonography; ultrasound.

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