J Perinatol

. 2022 Feb 28. doi: 10.1038/s41372-022-01357-x. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35228684/

Image-based prenatal predictors correlate with postnatal survival, extracorporeal life support use, and defect size in left congenital diaphragmatic hernia

Erin E Perrone ¹, Monita Karmakar ², Pamela A Lally ³, Sukyung Chung ⁴, Florian Kipfmueller ⁵, Francesco Morini ⁶, Ryan Phillips ⁷, Krisa P Van Meurs ⁸, Matthew T Harting ³, George B Mychaliska ², Kevin P Lally ³, Congenital Diaphragmatic Hernia Study GroupAffiliations expand

• PMID: 35228684
• DOI: 10.1038/s41372-022-01357-x

Abstract

Objective: To evaluate the association between prenatal imaging predictors of patients with left-sided congenital diaphragmatic hernia (LCDH) and postnatal outcomes.

Study design: CDH study group data were reviewed for LCDH infants born 2015-2019. Prenatal ultrasound (US) and magnetic resonance imaging (MRI) data were collected and correlated with postnatal information including CDHSG defect size (A through D or non-repair (NR)).

Results: In total, 929 LCDH patients were included. Both US and MRI imaging predictors correlated with postnatal survival (72.2%) and ECLS use (29.6%). Logistic regression models confirmed increased survival and decreased ECLS use with larger values for all predictors. Importantly, all prenatal values evaluated showed no significant difference between defect size D and NR patients.

Conclusions: This is the largest cohort of LCDH patients and demonstrates that prenatal imaging factors correlate with postnatal outcomes and confirms that patients in the non-repair group are prenatally similar to type D defects.

© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.