J Perinatol
. 2022 Aug 3.
doi: 10.1038/s41372-022-01470-x. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35922665/
Image-based prenatal predictors of postnatal survival, extracorporeal life support, and defect size in right congenital diaphragmatic hernia
Enrico Danzer 1, Valerie Y Chock 2, Sukyung Chung 3, Caroline Y Noh 2, Pamela A Lally 4, Matthew T Harting 4, Kevin P Lally 4, Erin E Perrone 5, Ashley H Ebanks 4, Krisa P van Meurs 2, Congenital Diaphragmatic Hernia Study Group
Collaborators, Affiliations expand
- PMID: 35922665
- DOI: 10.1038/s41372-022-01470-x
Abstract
Objective: To determine the association between prenatal ultrasound (US) and magnetic resonance imaging (MRI) characteristics in right congenital diaphragmatic hernia (RCDH) with postnatal outcome.
Study design: CDH Study Group data were reviewed for all RCDH infants (n = 156) born between 2015 and 2019. Prenatal US and MRI lung size measurements were correlated with survival, extracorporeal life support (ECLS), and defect size.
Result: Overall survival was 64.1%. ECLS was required in 40.4%. US and MRI-based prenatal assessment of pulmonary hypoplasia does not predict survival. Prenatal measurement of lung size using either US or MRI correlates with ECLS use. Only MRI-based measures of lung size are associated with defect size.
Conclusion: Image-based prenatal predictors of survival, ECLS, and defect size are of limited value in RCDH. Extrapolation of prenatal survival and morbidity indicators from left to right-sided CDH is not appropriate. There is an urgent need to develop RCDH prenatal prediction models.
© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.
