Prenat Diagn

. 2023 May 1.

 doi: 10.1002/pd.6365. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/37127552/

Neonatal outcomes of congenital diaphragmatic hernia in full term versus early term deliveries: A systematic review and meta-analysis

Kazuya Mimura ¹, Masayuki Endo ¹, Yoko Kawanishi ¹, Takeshi Kanagawa ², Kouji Nagata ³, Keita Terui ⁴, Makoto Fujii ⁵, Masayuki Shiraishi ⁶, Masaya Yamoto ⁷, Miharu Ito ⁸, Atsuo Itakura ⁹, Hiroomi Okuyama ¹⁰, Noriaki Usui ¹¹; Japanese Congenital Diaphragmatic Hernia Study Group

Affiliations expand

• PMID: 37127552
• DOI: 10.1002/pd.6365

Abstract

This systematic review and meta-analysis aimed to review the optimal timing of delivery at term for neonates with prenatally diagnosed congenital diaphragmatic hernia (CDH). We reviewed the literature up to December 19, 2022 using MEDLINE and the Cochrane Library databases. The inclusion criteria were original articles, comparative studies of CDH neonates delivered at an early term (37-38 weeks of gestation) and at full term (39 weeks of gestation or later), and comparative studies investigating outcomes of CDH neonates. Six studies met the inclusion criteria, including 985 neonates delivered at an early term and 629 delivered at full term. The cumulative rate of survival to discharge showed no significant difference between CDH neonates delivered at an early term (395/515; 76.7%) or at full term (345/467; 73.9%) (risk ratio [RR] 1.01; 95% confidence interval [CI], 0.89-1.16; p = 0.85). Furthermore, the number of neonates requiring oxygen therapy at discharge was not significantly different between CDH neonates delivered at an early term (32/370; 8.6%) and at full term (14/154; 9.1%) (RR, 0.99; 95% CI, 0.36-2.70; p = 0.99). Therefore, the optimal timing of delivery at term for neonates with CDH remains unclear.

© 2023 John Wiley & Sons Ltd.