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Research: Optimization of surgical timing of congenital diaphragmatic hernia using the quantified flow patterns of patent ductus arteriosus

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Research: Optimization of surgical timing of congenital diaphragmatic hernia using the quantified flow patterns of patent ductus arteriosus

Pediatr Surg Int

. 2021 Jan 3;1-7. doi: 10.1007/s00383-020-04788-9. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/33388956/

Optimization of surgical timing of congenital diaphragmatic hernia using the quantified flow patterns of patent ductus arteriosus

Yoshitaka Shinno 1Keita Terui 2Mamiko Endo 3Takeshi Saito 1Mitsuyuki Nakata 1Shugo Komatsu 1Satoru Oita 1Yoshio Katsumata 1Yukiko Saeda 1Genta Ozeki 1Yoshiteru Ohsone 3Tomoro Hishiki 1Affiliations expand

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Abstract

Purpose: The optimal timing of surgery for congenital diaphragmatic hernia (CDH) is controversial. We aimed to validate our protocol for the timing of CDH repair using the quantified patent ductus arteriosus (PDA) flow pattern.

Methods: This retrospective comparative study analyzed patients with a prenatal diagnosis of isolated CDH between 2007 and 2020. We defined the “LR ratio” as the percentage of velocity-time integral (VTI) of the left-to-right flow of PDA against overall VTI on echocardiography. Since 2010, we followed the decision criterion of performing surgery when LR ratio of > 50% has been achieved in the patients (protocol group). The protocol group (2010-2020) was compared with the historical control group (2007-2009).

Results: The average age at surgery was 104.1 ± 175.9 and 37.3 ± 30.6 h in the control and protocol groups, respectively (p = 0.11). Survival rate (88.9% vs. 95.0%, p = 0.53) and the rate of worsening of pulmonary hypertension within 24 h after surgery (22.2% vs. 10.0%, p = 0.57) were not different between the groups. The protocol group had a significantly shorter duration of tracheal intubation (26.9 ± 21.1 vs. 13.3 ± 9.5 days, p = 0.03).

Conclusion: Our decision criterion might have the advantage of facilitating early and safe surgery for patients with CDH.

Keywords: Congenital diaphragmatic hernia; Echocardiography; Patent ductus arteriosus; Pulmonary hypertension; Surgery.

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