Research: Outcomes of infants with congenital diaphragmatic hernia by side of defect in the FETO era.

Pediatr Surg Int. 2019 May 14. doi: 10.1007/s00383-019-04484-3. [Epub ahead of print]

Outcomes of infants with congenital diaphragmatic hernia by side of defect in the FETO era.

Ali K1Dassios T1,2Khaliq SA1Williams EE2Tamura K1,3Davenport M4Greenough A5,6,7,8.

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To compare the outcomes of infants with a right (RCDH) versus a left-sided (LCDH) congenital diaphragmatic hernia (CDH) and whether these differed according to whether the infants had undergone fetoscopic tracheal occlusion (FETO).


Demographics, the type of surgical repair, preoperative and postoperative courses and respiratory, gastrointestinal, surgical and skeletal morbidities at follow-up were compared between infants with a RCDH or LCDH. A sub-analysis was undertaken in those who had undergone FETO.


During the study period, there were 167 infants with a LCDH and 24 with a RCDH; 106 underwent FETO (15 RCDH). Overall, the need for inhaled nitric oxide (p = 0.036) was higher in the RCDH group and, at follow-up, infants with RCDH were more likely to have a hernia recurrence (p = 0.043), pectus deformity (p = 0.019), scoliosis (p = 0.029) and suffer chronic respiratory morbidity (p = 0.001). There were, however, no significant differences in short term or long term outcomes (hernia recurrence (p = 0.237), pectus deformity (p = 0.322), scoliosis (p = 0.0174) or chronic respiratory morbidity (p = 0.326)) between infants with a right or left sided CDH who had undergone FETO.


Overall, infants with a RCDH compared to those with a LCDH had greater long-term morbidity, but not if they had undergone FETO.


Congenital diaphragmatic hernia; Follow-up; Hernia recurrence; Survival PMID: 31089883 DOI: 10.1007/s00383-019-04484-3

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