Research: Perinatal stabilisation of infants born with congenital diaphragmatic hernia: a review of current concepts.

Arch Dis Child Fetal Neonatal Ed. 2020 Mar 13. pii: fetalneonatal-2019-318606. doi: 10.1136/archdischild-2019-318606. [Epub ahead of print]

Perinatal stabilisation of infants born with congenital diaphragmatic hernia: a review of current concepts.

Horn-Oudshoorn EJJ1Knol R1Te Pas AB2Hooper SB3Cochius-den Otter SCM4Wijnen RMH4Schaible T5Reiss IKM1DeKoninck PLJ6,7.

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Congenital diaphragmatic hernia (CDH) is associated with high mortality rates and significant pulmonary morbidity, mainly due to disrupted lung development related to herniation of abdominal organs into the chest. Pulmonary hypertension is a major contributor to both mortality and morbidity, however, treatment modalities are limited. Novel prenatal and postnatal interventions, such as fetal surgery and medical treatments, are currently under investigation. Until now, the perinatal stabilisation period immediately after birth has been relatively overlooked, although optimising support in these early stages may be vital in improving outcomes. Moreover, physiological parameters obtained from the perinatal stabilisation period could serve as early predictors of adverse outcomes, thereby facilitating both prevention and early treatment of these conditions. In this review, we focus on the perinatal stabilisation period by discussing the current delivery room guidelines in infants born with CDH, the physiological changes occurring during the fetal-to-neonatal transition in CDH, novel delivery room strategies and early predictors of adverse outcomes. The combination of improvements in the perinatal stabilisation period and early prediction of adverse outcomes may mitigate the need for specific postnatal management strategies.

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.


congenital abnorm; fetal medicine; neonatology; physiology; resuscitationPMID: 32170029 DOI: 10.1136/archdischild-2019-318606

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