Research: Re-ECMO for congenital diaphragmatic hernia: Is it worth the effort?

J Pediatr Surg. 2020 Apr 19. pii: S0022-3468(20)30265-7. doi: 10.1016/j.jpedsurg.2020.04.005. [Epub ahead of print]

Re-ECMO for congenital diaphragmatic hernia: Is it worth the effort?

Mesas Burgos C1Öst E2Frenckner B3.

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To evaluate the results in CDH patients subjected to a second course of ECMO at a single institution.


Retrospective review of medical charts of patients treated for CDH and ECMO in our center since 1990 to December 2018 was performed. For patients subjected to a second course of ECMO and who survived to hospital discharge charts from follow up visits were also reviewed.


From Jan 1990 until December 2018, 311 patients with CDH were treated in the department. 267 of these (86%) were discharged alive from the hospital and 81% (237/293) of the Swedish patients were alive by December 2018. 101 patients (32%) were subjected to ECMO treatment of whom 71 survived (70%). 22 patients underwent a second ECMO run and 13 of these survived to hospital discharge. Seven of the Swedish patients [19] were long-term survivors (37%). The vast majority was on V-A ECMO.


It is possible to recannulate the right common carotid artery and internal jugular vein for a second course of venoarterial ECMO in CDH patients, who deteriorate severely after decannulation. Previous research has shown that long-term survivors subjected to ECMO twice reported similar frequencies of pulmonary, gastrointestinal, neurological and musculoskeletal sequelae as the long-term survivors, who needed ECMO support only once, and similar health-related quality of life. Regarding their psychosocial function, they scored within normal range in the behavioral, emotional and social scales domains. A second ECMO run may contribute to a higher survival and that the long-term morbidity among survivors is not more pronounced than among survivors after a single course of ECMO. It is therefore suggested that a second course of ECMO should be offered on the same indications as the first course.


III Case series.

Copyright © 2020 Elsevier Inc. All rights reserved.


Congenital diaphragmatic hernia (CDH); Extracorporeal membrane oxygenation (ECMO); Long-term; Recannulation; SurvivalPMID: 32620266 DOI: 10.1016/j.jpedsurg.2020.04.005

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