Research: Role of MAGI2-AS3 in malignant and non-malignant disorders

Pathol Res Pract

. 2023 May 9;246:154530.

 doi: 10.1016/j.prp.2023.154530. Online ahead of print.

Role of MAGI2-AS3 in malignant and non-malignant disorders

Mohammad Taheri 1Arian Askari 2Bashdar Mahmud Hussen 3Soudeh Ghafouri-Fard 4Fariborz Rashnoo 5

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MAGI2 Antisense RNA 3 (MAGI2-AS3) is a long non-coding RNA (lncRNA) transcribed from a locus on 7q21.11. This lncRNA has been described to be abnormally expressed in a variety of malignancies in correlation with many clinical characteristics. Moreover, it might participate in the pathogenesis of congenital diaphragmatic hernia, Alzheimer’s disease and intervertebral disc degeneration. Mechanistically, MAGI2-AS3 can serve as a molecular sponge for miR-142-3p, miR-424-5p, miR-15b, miR-233, miR-452-5p, miR-629-5p, miR-25, miR-155, miR-23a-3p, miR-519c-3p, miR-374b-5p, miR-374a, miR-31-5p, miR-3163, miR-525-5p, miR-15-5p, miR-374a-5p, miR-374b-5p, miR-218-5p, miR-141-3p and miR-200a-3p to regulate expression of their mRNA targets. The current review summarizes the role of MAGI2-AS3 in different disorders to highlight its importance in their pathophysiology.

Keywords: Biomarker; Cancer; Expression; MAGI2-AS3; lncRNA.

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