Int J Mol Sci

. 2023 Apr 3;24(7):6656.

 doi: 10.3390/ijms24076656. https://pubmed.ncbi.nlm.nih.gov/37047629/

Role of microRNAs in Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension

Flaminia Pugnaloni ¹, Irma Capolupo ¹, Neil Patel ², Paola Giliberti ¹, Andrea Dotta ¹, Pietro Bagolan ^3 4, Florian Kipfmueller ⁵

Affiliations expand

• PMID: 37047629
• PMCID: PMC10095389
• DOI: 10.3390/ijms24076656

Free PMC article

Abstract

Epigenetic regulators such as microRNAs (miRNAs) have a key role in modulating several gene expression pathways and have a role both in lung development and function. One of the main pathogenetic determinants in patients with congenital diaphragmatic hernia (CDH) is pulmonary hypertension (PH), which is directly related to smaller lung size and pulmonary microarchitecture alterations. The aim of this review is to highlight the importance of miRNAs in CDH-related PH and to summarize the results covering this topic in animal and human CDH studies. The focus on epigenetic modulators of CDH-PH offers the opportunity to develop innovative diagnostic tools and novel treatment modalities, and provides a great potential to increase researchers’ understanding of the pathophysiology of CDH.

Keywords: congenital diaphragmatic hernia; epigenetics; microRNAs; pulmonary hypertension.