Research: Sepsis Screening of Neonatal Abdominal Surgery and Its Outcomes

J Indian Assoc Pediatr Surg

. 2022 Nov-Dec;27(6):677-683.

 doi: 10.4103/jiaps.jiaps_16_22. Epub 2022 Nov 14.

Sepsis Screening of Neonatal Abdominal Surgery and Its Outcomes

Ritesh Kumar 1 2Rajasekhar Addagatla 2Sandeep Kumar Jaglan 2Gali Divya 2Rishabh Jaju 3Pinaki Ranjan Debnath 2Amita Sen 2Shalu Shah 2

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Aim: The aim of this study was to evaluate the early indicators of sepsis (sepsis screening) and their statistical correlation with sepsis in neonatal abdominal surgery.

Materials and methods: A prospective observational study was performed on thirty consecutive neonate cases aged between 0 and 28 days with surgical abdomen at the Paediatric Surgery Department, ABVIMS and Dr. Ram Manohar Lohia Hospital, New Delhi. The study duration was 18 months. Septic screening was done in all neonates on day 0, 1, 3, 7, and 14 days of surgery with serum procalcitonin, C-reactive protein, total leukocyte count, immature/total neutrophil ratio, and microerythrocyte sedimentation rate. A septic screening-positive patient (three or more positive parameters out of five) was correlated with sepsis and analysis was done.

Results: A total of 30 neonates of abdominal surgical cases were included consequently, out of which 56.7% (n = 17) were male and 43.3% (n = 13) were female. Maximum cases were of congenital diaphragmatic hernia 20% (n = 6) and then anorectal malformation 16.7% (n = 5). About 70% of neonates were sepsis screening positive. Fifty percentage of neonates were diagnosed to have sepsis on the clinical or laboratory findings, so sensitivity and specificity of sepsis screening were 93.33% and 40%, respectively. There was total 30% mortality in this study.

Conclusion: Sepsis screening is an early marker of sepsis, which can be used to help in early detection of neonatal surgical sepsis and timely intervention that can lead to decrease mortality and morbidity in neonatal surgery.

Keywords: C-reactive protein; neonatal sepsis; neonatal surgery; procalcitonin; sepsis screening.

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