. 2023 May 9.
doi: 10.1002/pd.6383. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/37160690/
The grading of stomach position for postnatal outcomes in isolated left-sided congenital diaphragmatic hernia : A systematic review and meta-analysis
- PMID: 37160690
- DOI: 10.1002/pd.6383
Objectives: To evaluate the correlation between stomach position grading and postnatal outcomes in fetuses with isolated left-sided congenital diaphragmatic hernias (CDHs).
Methods: A literature search was conducted using the PubMed, Embase, and Cochrane Library database. The corresponding 95% CIs were used to assess the differences in the odds of mortality, according to the stomach position (SP) graded as level 0 to level 3. To evaluate the reliability of our results, a sensitivity analysis was also conducted.
Results: Nine papers with a total of 542 fetuses with isolated left-sided CDH were included. CDH pregnancies complicated by an intrathoracic stomach had higher odds of neonatal mortality when compared to intraabdominal stomach (odds ratio [OR] 2.86; 95% CI 1.38-5.94). Four papers with SP grading from level 0 to level 3 were included in a subgroup analysis. SP at level 1 and level 2 had lower odds of neonatal mortality when separately compared to level 3 (OR 0.12; 95% CI 0.04-0.33), (OR 0.30; 95% CI 0.16-0.54). SP at level 1 had lower odds of neonatal mortality when compared to level 2+3 (OR 0.25; 95% CI 0.09-0.66).
Conclusion: Survival of fetuses with isolated left-sided CDH is correlated with the stomach position. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.