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CDHi Attends BioData World Congress in Basel, Switzerland

Last week, the President of CDHi, Dawn Ireland, was in Basel, Switzerland attending BioData World Congress 2018 as one of only two patient advocates in a sea of pharma, data, and health experts. “It’s been very educational learning about blockchains, the different health databases (or lack of) in different countries, security and reminding everyone that …

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Current Fundraisers: Week of December 3rd

Here is a list of the current Facebook fundraisers benefiting CDH International and CHERUBS: Kayla’s fundraiser for CDH International in memory of Harlie Marino Hope’s fundraiser for CDH International Karen’s #GivingTuesday Fundraiser for CDH International Dawn’s fundraiser for CDH International for #GivingTuesday Becca’s #GivingTuesday Fundraiser for CDH International In memory for Payton #GivingTuesday Fundraiser for …

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RESEARCH: “Imaging of thoracic hernias: types and complications”

Thoracic hernias are characterised by either protrusion of the thoracic contents outside their normal anatomical confines or extension of the abdominal contents within the thorax. Thoracic hernias can be either congenital or acquired in aetiology. They can occur at the level of the thoracic inlet, chest wall or diaphragm. Thoracic hernias can be symptomatic or …

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RESEARCH: “A Multimodality Navigation System for Endoscopic Fetal Surgery: A Phantom Case Study for Congenital Diaphragmatic Hernia”

This article presents a multi-modality tracking and navigation system achieved by merging optical tracking and ultrasound imaging into a novel navigation software to help in surgical pre-planning and real-time target setting and guidance. Fetal surgeries require extensive experience in coordination of hand-eye-ultrasound-surgical equipment, knowledge, and precise assessment of relative anatomy. While there are navigation systems …

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RESEARCH: “Vascular and ventilatory mechanical responses in three different stages of pulmonary development in the rabbit model of congenital diaphragmatic hernia 1”

PURPOSE: To evaluate the vascular ventilatory response in different stages of lung development and to compare them to the neonates with congenital diaphragmatic hernia (CDH) in a rabbit model. METHODS: New Zealand rabbits were divided into 8 groups (n=5): E25, E27, E30, and CDH. All groups were ventilated on a FlexiVent (Scireq, Montreal, QC, Canada), …

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RESEARCH: “Morgagni hernia repair in children over two decades: Institutional experience, systematic review, and meta-analysis of 296 patients”

Morgagni diaphragmatic hernia (MH) is rare. We report our experience based on routine patch use in MH repair to curb recurrence. A systematic review and meta-analysis were performed to study the recurrence and complications associated with minimally invasive surgery and the use of patch. We retrospectively reviewed all cases of MH who underwent first-time repair …

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RESEARCH: “Ephrin-B1, -B2, and -B4 Expression is Decreased in Developing Diaphragms and Lungs of Fetal Rats with Nitrofen-Induced Congenital Diaphragmatic Hernia”

Congenital diaphragmatic hernia (CDH) is assumed to originate from a malformation of the amuscular mesenchymal component of the primordial diaphragm. Mutations in ephrin-B1, a membrane protein that is expressed by mesenchymal cells, have been found in newborn infants with CDH and associated pulmonary hypoplasia (PH), highlighting its important role during diaphragmatic and airway development. Ephrin-B1, …

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RESEARCH: “Medium and long-term respiratory outcome in patients operated from congenital diaphragmatic hernia: From a series of 56 patients”

Recent advances in prenatal diagnosis, high frequency oscillatory ventilation and pulmonary arterial hypertension (PAH) therapies have progressively improved the survival of patients with congenital diaphragmatic hernia (CDH). However, CDH is associated with high morbidity that affects about half of surviving children. The main sequelae observed are respiratory (asthma, persistent PAH [PPAH], bronchopulmonary dysplasia, respiratory infections) …

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RESEARCH: “Tracheal Diameter and Respiratory Outcome in Infants with Congenital Diaphragmatic Hernia Treated by Fetal Endoscopic Tracheal Occlusion”

AIM: To evaluate tracheal diameters and their clinical impact in patients with congenital diaphragmatic hernia (CDH) after fetal endoscopic tracheal occlusion (FETO).  METHODS: Patients born with CDH between January 2012 and August 2016 were divided into two groups: noFETO and FETO. Tracheal diameters at three levels (T1, carina, and maximum tracheal dilation) on chest X-ray at …